Literature DB >> 10931273

Peptide deformylase as a target for new generation, broad spectrum antimicrobial agents.

C Giglione1, M Pierre, T Meinnel.   

Abstract

Peptide deformylase was discovered 30 years ago, but as a result of its unusually unstable activity it was not fully characterized until very recently. The aim of this paper is to review the many recent data concerning this enzyme and to try to assess its potential as a target for future antimicrobial drugs.

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Year:  2000        PMID： 10931273     DOI： 10.1046/j.1365-2958.2000.01908.x

Source DB:  PubMed          Journal:  Mol Microbiol        ISSN： 0950-382X            Impact factor:   3.501


  37 in total

1.  Identification of eukaryotic peptide deformylases reveals universality of N-terminal protein processing mechanisms.

Authors:  C Giglione; A Serero; M Pierre; B Boisson; T Meinnel
Journal:  EMBO J       Date:  2000-11-01       Impact factor: 11.598

2.  Characterization of a novel fucose-regulated promoter (PfcsK) suitable for gene essentiality and antibacterial mode-of-action studies in Streptococcus pneumoniae.

Authors:  Pan F Chan; Karen M O'Dwyer; Leslie M Palmer; Jennifer D Ambrad; Karen A Ingraham; Chi So; Michael A Lonetto; Sanjoy Biswas; Martin Rosenberg; David J Holmes; Magdalena Zalacain
Journal:  J Bacteriol       Date:  2003-03       Impact factor: 3.490

3.  Identification of regions involved in enzymatic stability of peptide deformylase of Mycobacterium tuberculosis.

Authors:  Rahul Saxena; Pradip K Chakraborti
Journal:  J Bacteriol       Date:  2005-12       Impact factor: 3.490

4.  Phylogenomic and biochemical characterization of three Legionella pneumophila polypeptide deformylases.

Authors:  Jianzhong Huang; Glenn S Van Aller; Amy N Taylor; John J Kerrigan; Wu-Schyong Liu; Janice M Trulli; Zhihong Lai; David Holmes; Kelly M Aubart; James R Brown; Magdalena Zalacain
Journal:  J Bacteriol       Date:  2006-07       Impact factor: 3.490

5.  Reducing the fitness cost of antibiotic resistance by amplification of initiator tRNA genes.

Authors:  Annika I Nilsson; Anna Zorzet; Anna Kanth; Sabina Dahlström; Otto G Berg; Dan I Andersson
Journal:  Proc Natl Acad Sci U S A       Date:  2006-04-24       Impact factor: 11.205

6.  Formyl peptide receptors are candidate chemosensory receptors in the vomeronasal organ.

Authors:  Stephen D Liberles; Lisa F Horowitz; Donghui Kuang; James J Contos; Kathleen L Wilson; Jessica Siltberg-Liberles; David A Liberles; Linda B Buck
Journal:  Proc Natl Acad Sci U S A       Date:  2009-06-03       Impact factor: 11.205

7.  Relative quantitative comparisons of the extracellular protein profiles of Staphylococcus aureus UAMS-1 and its sarA, agr, and sarA agr regulatory mutants using one-dimensional polyacrylamide gel electrophoresis and nanocapillary liquid chromatography coupled with tandem mass spectrometry.

Authors:  Richard C Jones; Joanna Deck; Ricky D Edmondson; Mark E Hart
Journal:  J Bacteriol       Date:  2008-06-06       Impact factor: 3.490

8.  Mutations in three distinct loci cause resistance to peptide deformylase inhibitors in Bacillus subtilis.

Authors:  Yann Duroc; Carmela Giglione; Thierry Meinnel
Journal:  Antimicrob Agents Chemother       Date:  2009-01-26       Impact factor: 5.191

9.  Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics.

Authors:  Mona D Lee; Yuhong She; Michael J Soskis; Christopher P Borella; Jeffrey R Gardner; Paula A Hayes; Benzon M Dy; Mark L Heaney; Mark R Philips; William G Bornmann; Francis M Sirotnak; David A Scheinberg
Journal:  J Clin Invest       Date:  2004-10       Impact factor: 14.808

10.  FE(II) is the native cofactor for Escherichia coli methionine aminopeptidase.

Authors:  Sergio C Chai; Wen-Long Wang; Qi-Zhuang Ye
Journal:  J Biol Chem       Date:  2008-07-31       Impact factor: 5.157
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