Literature DB >> 16291698

Identification of regions involved in enzymatic stability of peptide deformylase of Mycobacterium tuberculosis.

Rahul Saxena1, Pradip K Chakraborti.   

Abstract

Sequence analysis of peptide deformylase of Mycobacterium tuberculosis revealed the presence of insertions (residues 74 to 85) and an unusually long carboxy-terminal end (residues 182 to 197). Our results with deletion mutants indicated the contribution of these regions in maintaining enzymatic stability. Furthermore, we showed that the region spanning the insertions was responsible for maintaining resistance to oxidizing agents, like H(2)O(2).

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Year:  2005        PMID： 16291698      PMCID： PMC1291256          DOI： 10.1128/JB.187.23.8216-8220.2005

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  19 in total

1.  Prediction of beta-turns in proteins from multiple alignment using neural network.

Authors:  Harpreet Kaur; Gajendra Pal Singh Raghava
Journal:  Protein Sci       Date:  2003-03       Impact factor: 6.725

2.  Structure analysis of peptide deformylases from Streptococcus pneumoniae, Staphylococcus aureus, Thermotoga maritima and Pseudomonas aeruginosa: snapshots of the oxygen sensitivity of peptide deformylase.

Authors:  Andreas Kreusch; Glen Spraggon; Chris C Lee; Heath Klock; Daniel McMullan; Ken Ng; Tanya Shin; Juli Vincent; Ian Warner; Christer Ericson; Scott A Lesley
Journal:  J Mol Biol       Date:  2003-07-04       Impact factor: 5.469

3.  The crystal structures of four peptide deformylases bound to the antibiotic actinonin reveal two distinct types: a platform for the structure-based design of antibacterial agents.

Authors:  Jean-Pierre Guilloteau; Magali Mathieu; Carmela Giglione; Véronique Blanc; Alain Dupuy; Miline Chevrier; Patricia Gil; Alain Famechon; Thierry Meinnel; Vincent Mikol
Journal:  J Mol Biol       Date:  2002-07-26       Impact factor: 5.469

4.  Peptide deformylase in Staphylococcus aureus: resistance to inhibition is mediated by mutations in the formyltransferase gene.

Authors:  P S Margolis; C J Hackbarth; D C Young; W Wang; D Chen; Z Yuan; R White; J Trias
Journal:  Antimicrob Agents Chemother       Date:  2000-07       Impact factor: 5.191

5.  Peptide deformylase as an antibacterial drug target: target validation and resistance development.

Authors:  C M Apfel; H Locher; S Evers; B Takács; C Hubschwerlen; W Pirson; M G Page; W Keck
Journal:  Antimicrob Agents Chemother       Date:  2001-04       Impact factor: 5.191

6.  Resistance of Streptococcus pneumoniae to deformylase inhibitors is due to mutations in defB.

Authors:  P Margolis; C Hackbarth; S Lopez; M Maniar; W Wang; Z Yuan; R White; J Trias
Journal:  Antimicrob Agents Chemother       Date:  2001-09       Impact factor: 5.191

7.  Crystal structure of type II peptide deformylase from Staphylococcus aureus.

Authors:  Eric T Baldwin; Melissa S Harris; Anthony W Yem; Cindy L Wolfe; Anne F Vosters; Kimberly A Curry; Robert W Murray; Jeffrey H Bock; Vincent P Marshall; Joyce I Cialdella; Mahesh H Merchant; Gil Choi; Martin R Deibel
Journal:  J Biol Chem       Date:  2002-06-04       Impact factor: 5.157

8.  The carboxy-terminal end of the peptide deformylase from Mycobacterium tuberculosis is indispensable for its enzymatic activity.

Authors:  Rahul Saxena; Pradip K Chakraborti
Journal:  Biochem Biophys Res Commun       Date:  2005-07-01       Impact factor: 3.575

9.  Functional and analytical evidence for scavenging of oxygen radicals by L-arginine.

Authors:  Achim Lass; Astrid Suessenbacher; Gerald Wölkart; Bernd Mayer; Friedrich Brunner
Journal:  Mol Pharmacol       Date:  2002-05       Impact factor: 4.436

10.  Enzymatic properties of a new peptide deformylase from pathogenic bacterium Leptospira interrogans.

Authors:  Yikun Li; Zhifeng Chen; Weimin Gong
Journal:  Biochem Biophys Res Commun       Date:  2002-07-26       Impact factor: 3.575
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  4 in total

1.  High tolerance to mutations in a Chlamydia trachomatis peptide deformylase loop.

Authors:  Christopher B Oey; Xiaofeng Bao; Christal Lewis; John E Kerrigan; Huizhou Fan
Journal:  World J Biol Chem       Date:  2011-05-26

2.  Peptide deformylase inhibitors as potent antimycobacterial agents.

Authors:  Jeanette W P Teo; Pamela Thayalan; David Beer; Amelia S L Yap; Mahesh Nanjundappa; Xinyi Ngew; Jeyaraj Duraiswamy; Sarah Liung; Veronique Dartois; Mark Schreiber; Samiul Hasan; Michael Cynamon; Neil S Ryder; Xia Yang; Beat Weidmann; Kathryn Bracken; Thomas Dick; Kakoli Mukherjee
Journal:  Antimicrob Agents Chemother       Date:  2006-09-11       Impact factor: 5.191

3.  Three consecutive arginines are important for the mycobacterial peptide deformylase enzyme activity.

Authors:  Rahul Saxena; Pavitra Kanudia; Manish Datt; Haider Hussain Dar; Subramanian Karthikeyan; Balvinder Singh; Pradip K Chakraborti
Journal:  J Biol Chem       Date:  2008-06-23       Impact factor: 5.157

4.  Identification of crucial amino acids of bacterial Peptide deformylases affecting enzymatic activity in response to oxidative stress.

Authors:  Sanjay Kumar; Pavitra Kanudia; Subramanian Karthikeyan; Pradip K Chakraborti
Journal:  J Bacteriol       Date:  2013-10-18       Impact factor: 3.490
  4 in total

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