Literature DB >> 10930503

Primary structure, functional characteristics and tissue expression pattern of human ATA2, a subtype of amino acid transport system A.

T Hatanaka1, W Huang, H Wang, M Sugawara, P D Prasad, F H Leibach, V Ganapathy.   

Abstract

We report here on the primary structure and functional characteristics of the protein responsible for the system A amino acid transport activity that is known to be expressed in most human tissues. This transporter, designated ATA2 for amino acid transporter A2, was cloned from the human hepatoma cell line HepG2. Human ATA2 (hATA2) consists of 506 amino acids and exhibits a high degree of homology to rat ATA2. hATA2-specific mRNA is ubiquitously expressed in human tissues. When expressed in mammalian cells, hATA2 mediates Na+-dependent transport of alpha-(methylamino)isobutyric acid, a specific model substrate for system A. The transporter is specific for neutral amino acids. It is pH-sensitive and Li+-intolerant. The Na+:amino acid stoichiometry is 1:1.

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Year:  2000        PMID： 10930503     DOI： 10.1016/s0005-2736(00)00252-2

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  35 in total

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2.  L-methionine placental uptake: characterization and modulation in gestational diabetes mellitus.

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3.  Homocysteine transport by systems L, A and y+L across the microvillous plasma membrane of human placenta.

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4.  Ontogeny of the neutral amino acid transporter SNAT1 in the developing rat.

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5.  Glucagon's effect on liver protein metabolism in vivo.

Authors:  Guillaume Kraft; Katie C Coate; Jason J Winnick; Dominique Dardevet; E Patrick Donahue; Alan D Cherrington; Phillip E Williams; Mary Courtney Moore
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7.  The Concise Guide to PHARMACOLOGY 2013/14: transporters.

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Review 8.  Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family.

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10.  The SNAT4 isoform of the system A amino acid transporter is functional in human placental microvillous plasma membrane.

Authors:  M Desforges; K J Mynett; R L Jones; S L Greenwood; M Westwood; C P Sibley; J D Glazier
Journal:  J Physiol       Date:  2008-11-17       Impact factor: 5.182
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