OBJECT: The magnetic stereotaxis system (MSS) is a device designed to direct catheter tips through magnetic forces. In this study the authors tested the safety and performance of the MSS in directing catheters through a nonlinear path to obtain biopsy specimens in pig brains. METHODS: Sixteen pigs underwent biopsy of the frontal brain region with the aid of an MSS (11 pigs) or a standard stereotactic biopsy tool (five pigs). Surgical preparation consisted of placement of six fiducial markers in the skull and the creation of a burr hole for attachment of a cranial bolt and passage of the biopsy catheter. The pigs underwent magnetic resonance (MR) imaging of the head to define a biopsy target and to plan a nonlinear path. Guided by the MSS, which used nearly real-time fluoroscopic imaging fused to the preoperative MR image, the authors advanced a catheter to the biopsy target. A biopsy tool was passed through the catheter and a tissue sample was obtained. The animals were observed for 3 to 5 days postoperatively, when they were assessed for neurological abnormalities or other signs of morbidity. Actual catheter placement was within 1.5 mm of the planned path to the biopsy site, using a minimum path radius of 30 mm. The registration error associated with the use of the MSS x-ray fluoroscopy and MR imaging averaged 1.7 mm. Tissue disruption caused by the MSS was similar to that of standard stereotactic procedures. CONCLUSIONS: The MSS affords accurate and safe guidance of brain catheters in animals. The application tested here, brain biopsy, is one of a number of potential catheter-guided procedures.
OBJECT: The magnetic stereotaxis system (MSS) is a device designed to direct catheter tips through magnetic forces. In this study the authors tested the safety and performance of the MSS in directing catheters through a nonlinear path to obtain biopsy specimens in pig brains. METHODS: Sixteen pigs underwent biopsy of the frontal brain region with the aid of an MSS (11 pigs) or a standard stereotactic biopsy tool (five pigs). Surgical preparation consisted of placement of six fiducial markers in the skull and the creation of a burr hole for attachment of a cranial bolt and passage of the biopsy catheter. The pigs underwent magnetic resonance (MR) imaging of the head to define a biopsy target and to plan a nonlinear path. Guided by the MSS, which used nearly real-time fluoroscopic imaging fused to the preoperative MR image, the authors advanced a catheter to the biopsy target. A biopsy tool was passed through the catheter and a tissue sample was obtained. The animals were observed for 3 to 5 days postoperatively, when they were assessed for neurological abnormalities or other signs of morbidity. Actual catheter placement was within 1.5 mm of the planned path to the biopsy site, using a minimum path radius of 30 mm. The registration error associated with the use of the MSS x-ray fluoroscopy and MR imaging averaged 1.7 mm. Tissue disruption caused by the MSS was similar to that of standard stereotactic procedures. CONCLUSIONS: The MSS affords accurate and safe guidance of brain catheters in animals. The application tested here, brain biopsy, is one of a number of potential catheter-guided procedures.
Authors: T Krings; J Finney; P Niggemann; P Reinacher; N Lück; A Drexler; J Lovell; A Meyer; R Sehra; P Schauerte; M Reinges; F J Hans; A Thron Journal: Neuroradiology Date: 2006-04-19 Impact factor: 2.804
Authors: Guilherme Dabus; Ronald J Gerstle; Dewitte T Cross; Colin P Derdeyn; Christopher J Moran Journal: Neuroradiology Date: 2007-01-11 Impact factor: 2.804
Authors: E Antonio Chiocca; William C Broaddus; George T Gillies; Therese Visted; Martine L M Lamfers Journal: J Neurooncol Date: 2004 Aug-Sep Impact factor: 4.130
Authors: Yoonho Kim; Emily Genevriere; Pablo Harker; Jaehun Choe; Marcin Balicki; Robert W Regenhardt; Justin E Vranic; Adam A Dmytriw; Aman B Patel; Xuanhe Zhao Journal: Sci Robot Date: 2022-04-13
Authors: Ryan S Sincic; Curtis J Caton; Prasheel Lillaney; Scott Goodfriend; Jason Ni; Alastair J Martin; Aaron D Losey; Neel Shah; Erin J Yee; Lee Evans; Vincent Malba; Anthony F Bernhardt; Fabio Settecase; Daniel L Cooke; Maythem Saeed; Mark W Wilson; Steven W Hetts Journal: Biomed Microdevices Date: 2014-02 Impact factor: 2.838