Literature DB >> 10926671

Invited review: what do we know about the effects of spaceflight on bone?

R T Turner1.   

Abstract

This review of the peer-reviewed literature focuses on the effects of spaceflight on bone. Studies performed in humans and laboratory animals have revealed abnormalities in bone and mineral metabolism that suggest that long-duration spaceflight will have detrimental effects on the skeleton. However, because of large gaps in our knowledge, it is not presently possible to estimate the magnitude of the health risk, individual variations in risk, effective countermeasures, or mechanism(s) of action. Specific recommendations are made for future research to ascertain risk and develop appropriate countermeasures.

Entities:  

Keywords:  NASA Discipline Musculoskeletal; Non-NASA Center

Mesh：

Year:  2000        PMID： 10926671     DOI： 10.1152/jappl.2000.89.2.840

Source DB:  PubMed          Journal:  J Appl Physiol (1985)        ISSN： 0161-7567


  22 in total

1.  Osteoblasts subjected to spaceflight and simulated space shuttle launch conditions.

Authors:  Melissa A Kacena; Paul Todd; William J Landis
Journal:  In Vitro Cell Dev Biol Anim       Date:  2003 Nov-Dec       Impact factor: 2.416

2.  Biomechanical analysis of running in weightlessness on a treadmill equipped with a subject loading system.

Authors:  Thierry P Gosseye; Patrick A Willems; Norman C Heglund
Journal:  Eur J Appl Physiol       Date:  2010-06-27       Impact factor: 3.078

Review 3.  The next small step.

Authors:  Kevin Fong
Journal:  BMJ       Date:  2004-12-18

4.  Simulated microgravity inhibits the proliferation and osteogenesis of rat bone marrow mesenchymal stem cells.

Authors:  Z Q Dai; R Wang; S K Ling; Y M Wan; Y H Li
Journal:  Cell Prolif       Date:  2007-10       Impact factor: 6.831

Review 5.  Influence of body weight on bone mass, architecture and turnover.

Authors:  Urszula T Iwaniec; Russell T Turner
Journal:  J Endocrinol       Date:  2016-06-27       Impact factor: 4.286

6.  Impact of simulated microgravity on microvascular endothelial cell apoptosis.

Authors:  Chun-Yan Kang; Lin Zou; Ming Yuan; Yang Wang; Tian-Zhi Li; Ye Zhang; Jun-Feng Wang; Yan Li; Xiao-Wei Deng; Chang-Ting Liu
Journal:  Eur J Appl Physiol       Date:  2011-02-02       Impact factor: 3.078

7.  Whole-body vibration and resistance exercise prevent long-term hindlimb unloading-induced bone loss: independent and interactive effects.

Authors:  Zhili Li; Cheng Tan; Yonghua Wu; Ye Ding; Huijuan Wang; Wenjuan Chen; Yu Zhu; Honglei Ma; Honghui Yang; Wenbin Liang; Shizhong Jiang; Desheng Wang; Linjie Wang; Guohua Tang; Jun Wang
Journal:  Eur J Appl Physiol       Date:  2012-02-28       Impact factor: 3.078

8.  Partial weight suspension: a novel murine model for investigating adaptation to reduced musculoskeletal loading.

Authors:  Erika B Wagner; Nicholas P Granzella; Hiroaki Saito; Dava J Newman; Laurence R Young; Mary L Bouxsein
Journal:  J Appl Physiol (1985)       Date:  2010-06-03

9.  The influence of disuse on bone microstructure and mechanics assessed by HR-pQCT.

Authors:  Galateia J Kazakia; Willy Tjong; Jasmine A Nirody; Andrew J Burghardt; Julio Carballido-Gamio; Janina M Patsch; Thomas Link; Brian T Feeley; C Benjamin Ma
Journal:  Bone       Date:  2014-03-03       Impact factor: 4.398

10.  Morphological, physiological and behavioural evaluation of a 'Mice in Space' housing system.

Authors:  Dieter Blottner; Najet Serradj; Michele Salanova; Chadi Touma; Rupert Palme; Mitchell Silva; Jean Marie Aerts; Daniel Berckmans; Laurence Vico; Yi Liu; Alessandra Giuliani; Franco Rustichelli; Ranieri Cancedda; Marc Jamon
Journal:  J Comp Physiol B       Date:  2009-01-08       Impact factor: 2.200
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