Literature DB >> 10926152

Numerical studies of blood shear and washing in a continuous flow ventricular assist device.

J B Anderson1, H G Wood, P E Allaire, J C McDaniel, D B Olsen, G Bearnson.   

Abstract

The third prototype of a continuous flow ventricular assist device (CF3) is being developed and tested for implantation in humans. The blood in the pump flows through a fully shrouded four bladed impeller (supported by magnetic bearings) and through small clearance regions on either side of the impeller. Computational fluid dynamics (CFD) solutions for this flow have been obtained by using TascFlow, a software package available from AEA Technology, UK. These flow solutions have been used to estimate the shear stresses on the blood in the pump and, hence, to minimize hemolysis. In addition, the solutions are informative for achieving a design that will provide good washing of the blood to minimize the possibility of stagnation points that can lead to thrombosis. This study presents numerical studies of these phenomena in the CF3. The calculated shear rate results are compared with values published in the open literature. The comparisons indicate that hemolysis will not be a problem with CF3, which is in agreement with preliminary experimental measurements. Flow studies are being conducted to determine the optimal size of the clearance regions.

Entities:  

Mesh:

Year:  2000        PMID: 10926152     DOI: 10.1097/00002480-200007000-00024

Source DB:  PubMed          Journal:  ASAIO J        ISSN: 1058-2916            Impact factor:   2.872


  8 in total

Review 1.  The use of computational fluid dynamics in the development of ventricular assist devices.

Authors:  Katharine H Fraser; M Ertan Taskin; Bartley P Griffith; Zhongjun J Wu
Journal:  Med Eng Phys       Date:  2010-11-13       Impact factor: 2.242

2.  Estimation of changes in dynamic hydraulic force in a magnetically suspended centrifugal blood pump with transient computational fluid dynamics analysis.

Authors:  Toru Masuzawa; Akiko Ohta; Nobuatu Tanaka; Yi Qian; Tomonori Tsukiya
Journal:  J Artif Organs       Date:  2009-09-19       Impact factor: 1.731

3.  High shear induces platelet dysfunction leading to enhanced thrombotic propensity and diminished hemostatic capacity.

Authors:  Zengsheng Chen; Nandan K Mondal; Shirong Zheng; Steven C Koenig; Mark S Slaughter; Bartley P Griffith; Zhongjun J Wu
Journal:  Platelets       Date:  2017-11-28       Impact factor: 3.862

4.  Proposal of hemodynamically improved design of an axial flow blood pump for LVAD.

Authors:  Vikas Kannojiya; Arup Kumar Das; Prasanta Kumar Das
Journal:  Med Biol Eng Comput       Date:  2019-12-19       Impact factor: 2.602

5.  Shear-induced platelet receptor shedding by non-physiological high shear stress with short exposure time: glycoprotein Ibα and glycoprotein VI.

Authors:  Zengsheng Chen; Nandan K Mondal; Jun Ding; Jingya Gao; Bartley P Griffith; Zhongjun J Wu
Journal:  Thromb Res       Date:  2015-02-07       Impact factor: 3.944

6.  Comparison and experimental validation of fluid dynamic numerical models for a clinical ventricular assist device.

Authors:  Jiafeng Zhang; Pei Zhang; Katharine H Fraser; Bartley P Griffith; Zhongjun J Wu
Journal:  Artif Organs       Date:  2013-02-27       Impact factor: 3.094

7.  Quantitative Characterization of Shear-Induced Platelet Receptor Shedding: Glycoprotein Ibα, Glycoprotein VI, and Glycoprotein IIb/IIIa.

Authors:  Zengsheng Chen; Steven C Koenig; Mark S Slaughter; Bartley P Griffith; Zhongjun J Wu
Journal:  ASAIO J       Date:  2018 Nov/Dec       Impact factor: 2.872

8.  A Multi-Domain Simulation Study of a Pulsatile-Flow Pump Device for Heart Failure With Preserved Ejection Fraction.

Authors:  Caglar Ozturk; Luca Rosalia; Ellen T Roche
Journal:  Front Physiol       Date:  2022-01-25       Impact factor: 4.566

  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.