Literature DB >> 31858420

Proposal of hemodynamically improved design of an axial flow blood pump for LVAD.

Vikas Kannojiya1, Arup Kumar Das2, Prasanta Kumar Das3.   

Abstract

Left ventricular assist devices (LVAD) emerges as an effective clinical device providing life-saving support to heart patients. The design of blood pump of an LVAD involves incredible accuracy and thorough understanding of hemodynamics to mimic the functionality of a healthy ventricle. This work studies hemodynamics around an LVAD and proposes an improved model of axial blood pump for cardiac circulation without any hemolysis complications through numerical investigations. A three-dimensional study on different versions of the impeller with three curved blades (pump I) and spiral blade (pump II) is carried out by utilizing computational fluid dynamics software ANSYS-CFX at a range of rotational speeds and flow rates. The non-Newtonian blood flow through pump is modeled by using Bird-Carreau model. To capture the change in the flow field near the rotating blade, a transient blade row model was employed. The proposal of spiral blade impeller was found to be more compatible as per the hemolytic performance. It considerably reduces the blood damage to two times lesser value than that by pump I and also improves the quality blood flow field. The spiral blade provides a guiding path to the blood particle and avoids mixing of different bloodstreams, thus reducing the eddy losses. Graphical abstract The graphical abstract shows the performance enhancement of the axial blood pump. The model proposed by Peng et al. (Comput Methods Biomech Biomed Engin 17(7):723-727, 2014) has been upgraded to two new versions by redesigning its impeller. Proposed design (pump II) shows improvement in pressure distribution (a) and reduction in hemolysis (in the case of pump II) index (b).

Entities:  

Keywords:  Axial blood pump; CFD; Damage index estimates; Hemolysis; Non-Newtonian modeling

Mesh:

Year:  2019        PMID: 31858420     DOI: 10.1007/s11517-019-02097-5

Source DB:  PubMed          Journal:  Med Biol Eng Comput        ISSN: 0140-0118            Impact factor:   2.602


  30 in total

1.  Numerical studies of blood shear and washing in a continuous flow ventricular assist device.

Authors:  J B Anderson; H G Wood; P E Allaire; J C McDaniel; D B Olsen; G Bearnson
Journal:  ASAIO J       Date:  2000 Jul-Aug       Impact factor: 2.872

2.  Computational characterization of flow and hemolytic performance of the UltraMag blood pump for circulatory support.

Authors:  M Ertan Taskin; Katharine H Fraser; Tao Zhang; Barry Gellman; Andi Fleischli; Kurt A Dasse; Bartley P Griffith; Zhongjun J Wu
Journal:  Artif Organs       Date:  2010-12       Impact factor: 3.094

3.  Effects of the non-Newtonian viscosity of blood on flows in a diseased arterial vessel. Part 1: Steady flows.

Authors:  Y I Cho; K R Kensey
Journal:  Biorheology       Date:  1991       Impact factor: 1.875

4.  Design of a centrifugal blood pump: Heart Turcica Centrifugal.

Authors:  Onur Demir; Emre Biyikli; Ismail Lazoglu; Suha Kucukaksu
Journal:  Artif Organs       Date:  2011-03-01       Impact factor: 3.094

5.  Red cell injury assessed in a numeric model of a peripheral dialysis needle.

Authors:  D S De Wachter; P R Verdonck; R F Verhoeven; R O Hombrouckx
Journal:  ASAIO J       Date:  1996 Sep-Oct       Impact factor: 2.872

6.  The Rheology of Blood Flow in a Branched Arterial System.

Authors:  Shewaferaw S Shibeshi; William E Collins
Journal:  Appl Rheol       Date:  2005       Impact factor: 1.581

7.  Hemolysis in left ventricular assist device: a retrospective analysis of outcomes.

Authors:  Ashwin K Ravichandran; Jeffery Parker; Eric Novak; Susan M Joseph; Joel D Schilling; Gregory A Ewald; Scott Silvestry
Journal:  J Heart Lung Transplant       Date:  2013-11-14       Impact factor: 10.247

8.  Red blood cell damage by shear stress.

Authors:  L B Leverett; J D Hellums; C P Alfrey; E C Lynch
Journal:  Biophys J       Date:  1972-03       Impact factor: 4.033

9.  Advanced heart failure treated with continuous-flow left ventricular assist device.

Authors:  Mark S Slaughter; Joseph G Rogers; Carmelo A Milano; Stuart D Russell; John V Conte; David Feldman; Benjamin Sun; Antone J Tatooles; Reynolds M Delgado; James W Long; Thomas C Wozniak; Waqas Ghumman; David J Farrar; O Howard Frazier
Journal:  N Engl J Med       Date:  2009-11-17       Impact factor: 91.245

10.  Extending the Power-Law Hemolysis Model to Complex Flows.

Authors:  Mohammad M Faghih; M Keith Sharp
Journal:  J Biomech Eng       Date:  2016-12-01       Impact factor: 2.097

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  1 in total

1.  Hemolytic Performance in Two Generations of the Sputnik Left Ventricular Assist Device: A Combined Numerical and Experimental Study.

Authors:  Alexandra N Romanova; Alexander A Pugovkin; Maxim V Denisov; Ivan A Ephimov; Dmitry V Gusev; Marian Walter; Thomas Groth; Olga L Bockeria; Tatyana G Le; Anna S Satyukova; Sergey V Selishchev; Dmitry V Telyshev
Journal:  J Funct Biomater       Date:  2022-01-12
  1 in total

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