Literature DB >> 10923819

Synthesis of diaryl-substituted imidazo[l,2-a]pyridines designed as potential aromatase inhibitors.

C Enguehard1, J L Renou, H Allouchi, J M Leger, A Gueiffier.   

Abstract

From a pharmacophore model of bicyclic heterocycles as aromatase inhibitors we have designed three series of imidazo[1,2-a]pyridine derivatives. The synthesis and the spectroscopy determination of various compounds are reported. The crystal data of one of these compounds (10b) was obtained. The aromatase inhibition potency was evaluated in vitro and no activity was found.

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Year:  2000        PMID： 10923819     DOI： 10.1248/cpb.48.935

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  4 in total

1.  Metal-free, efficient hydrazination of imidazo[1,2-a]pyridine with diethyl azodicarboxylate in neutral media.

Authors:  Yuanxiang Wang; Brendan Frett; Nick McConnell; Hong-Yu Li
Journal:  Org Biomol Chem       Date:  2015-03-14       Impact factor: 3.876

2.  Efficient access to 2,3-diarylimidazo[1,2-a]pyridines via a one-pot, ligand-free, palladium-catalyzed three-component reaction under microwave irradiation.

Authors:  Yuanxiang Wang; Brendan Frett; Hong-yu Li
Journal:  Org Lett       Date:  2014-05-22       Impact factor: 6.005

3.  Novel (+)-Neoisopulegol-Based O-Benzyl Derivatives as Antimicrobial Agents.

Authors:  Tam Minh Le; Thu Huynh; Fatima Zahra Bamou; András Szekeres; Ferenc Fülöp; Zsolt Szakonyi
Journal:  Int J Mol Sci       Date:  2021-05-26       Impact factor: 5.923

4.  Microwave assisted synthesis of bis and tris(ω-bromoacetophenones): versatile precursors for novel bis(imidazo[1,2-a]pyridines), bis(imidazo[1,2-a]pyrimidines) and their tris-analogs.

Authors:  Mohamed R Shaaban
Journal:  Chem Cent J       Date:  2013-06-19       Impact factor: 4.215
  4 in total

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