Literature DB >> 10921601

Using potentially life-shortening drugs in neonates and infants.

A van der Heide1, P J van der Maas, G van der Wal, L A Kollée, R de Leeuw.   

Abstract

OBJECTIVE: To describe the frequency, background, and impact of decisions to give analgesic or other drugs that may, intentionally or unintentionally, shorten the life-span of severely ill neonates.
SETTING: The Netherlands.
DESIGN: Retrospective, cross-sectional study. PATIENTS: Questionnaires were mailed in The Netherlands to physicians reporting 338 consecutive deaths of infants under 1 yr of age from August through November 1995.
INTERVENTIONS: None.
MEASUREMENTS AND MAIN RESULTS: Questions were asked about medical end-of-life decisions preceding the death of the infant and about the decision-making process. Potentially life-shortening drugs, mostly opioids, were given in 37% of all deaths. The estimated effect in terms of the shortening of life was <1 wk in 72% of all patients in whom the administration of potentially life-shortening drugs had been the most important end-of-life decision. Most decisions to administer such drugs were discussed with parents and colleagues. The decisions were discussed regarding virtually all patients in whom the physician had intended to hasten death; doses of opioids tended to be larger in this group.
CONCLUSIONS: The frequency with which drugs that may shorten life are administered before the death of severely ill infants confirms the important role of modern medicine in dying in neonatology. Most physicians caring for neonates feel that palliative medication may be warranted in dying infants, even if it shortens life. A distinction between intentionally ending life and providing adequate terminal care by alleviating pain or other symptoms, which is important in moral and judicial terms, is probably not easily made for some of these patients.

Entities:  

Keywords:  Death and Euthanasia; Empirical Approach; Professional Patient Relationship

Mesh:

Substances:

Year:  2000        PMID: 10921601     DOI: 10.1097/00003246-200007000-00069

Source DB:  PubMed          Journal:  Crit Care Med        ISSN: 0090-3493            Impact factor:   7.598


  5 in total

1.  The use of drugs with a life-shortening effect in end-of-life care in neonates and infants.

Authors:  Veerle Provoost; Filip Cools; Johan Bilsen; José Ramet; Peter Deconinck; Robert Vander Stichele; Anne Vande Velde; Inge Van Herreweghe; Freddy Mortier; Yvan Vandenplas; Luc Deliens
Journal:  Intensive Care Med       Date:  2005-11-15       Impact factor: 17.440

2.  Considerations about hastening death among parents of children who die of cancer.

Authors:  Veronica Dussel; Steven Joffe; Joanne M Hilden; Jan Watterson-Schaeffer; Jane C Weeks; Joanne Wolfe
Journal:  Arch Pediatr Adolesc Med       Date:  2010-03

3.  Relationship of neonatologists' end-of-life decisions to their personal fear of death.

Authors:  Peter Barr
Journal:  Arch Dis Child Fetal Neonatal Ed       Date:  2007-02-06       Impact factor: 5.747

4.  Should euthanasia be legal? An international survey of neonatal intensive care units staff.

Authors:  M Cuttini; V Casotto; M Kaminski; I de Beaufort; I Berbik; G Hansen; L Kollée; A Kucinskas; S Lenoir; A Levin; M Orzalesi; J Persson; M Rebagliato; M Reid; R Saracci
Journal:  Arch Dis Child Fetal Neonatal Ed       Date:  2004-01       Impact factor: 5.747

5.  Sedatives and Analgesics Given to Infants in Neonatal Intensive Care Units at the End of Life.

Authors:  Kanecia O Zimmerman; Christoph P Hornik; Lawrence Ku; Kevin Watt; Matthew M Laughon; Margarita Bidegain; Reese H Clark; P Brian Smith
Journal:  J Pediatr       Date:  2015-05-23       Impact factor: 6.314

  5 in total

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