| Literature DB >> 10915039 |
K R Gee1, E A Archer, L A Lapham, M E Leonard, Z L Zhou, J Bingham, Z Diwu.
Abstract
Mono-halogenated derivatives of the calcium indicators fura-2 and indo-1 were synthesized and their spectroscopic properties evaluated. Halogenation ortho or para to the bridging oxygen in the BAPTA nucleus had a more pronounced weakening effect on binding affinity than in the meta position in the fura derivatives. Two new excitation ratioable fluorescent calcium indicators, benzothiaza-1 and 2, were also synthesized. Kd values of 400 nM to 5.3 microM [Ca2+] were observed in these families of new probes.Entities:
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Year: 2000 PMID： 10915039 DOI： 10.1016/s0960-894x(00)00280-8
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823