Literature DB >> 10913842

Chemical characterization of milk oligosaccharides of the polar bear, Ursus maritimus.

T Urashima1, T Yamashita, T Nakamura, I Arai, T Saito, A E Derocher, O Wiig.   

Abstract

Two trisaccharides, three tetrasaccharides, two pentasaccharides, one hexasaccharide, one heptasaccharide, one octasaccharide and one decasaccharide were isolated from polar bear milk samples by chloroform/methanol extraction, gel filtration, ion exchange chromatography and preparative thin-layer chromatography. The oligosaccharides were characterized by 1H-NMR as follows: the saccharides from one animal: Gal(alpha1-3)Gal(beta1-4)Glc (alpha3'-galactosyllactose), Fuc(alpha1-2)Gal(beta1-4)Glc (2'-fucosyllactose), Gal(alpha1-3)[Fuc(alpha1-2)]Gal(beta1-4)Glc (B-tetrasaccharide), GalNAc(alpha1-3)[Fuc(alpha1-2)]Gal(beta1-4)Glc (A-tetrasaccharide), Gal(alpha1-3)Gal(beta1-4)GlcNAc(beta1-3)Gal(beta1-4)Glc, Gal(alpha1-3)[Fuc(alpha1-2)]Gal(beta1-4)GlcNAc(beta1-3)Gal(beta1-4)Gl c, Gal(alpha1-3)Gal(beta1-4)GlcNAc(beta1-3)[Gal(alpha1-3)Gal(beta1-4)Glc NAc(beta1-6)]Gal(beta1-4)Glc; the saccharides from another animal: alpha3'-galactosyllactose, Gal(alpha1-3)Gal(beta1-4)[Fuc(alpha1-3)]Glc, A-tetrasaccharide, GalNAc(alpha1-3)[Fuc(alpha1-2)]Gal(beta1-4)[Fuc(alpha1-3)]Glc (A-pentasaccharide), Gal(alpha1-3)Gal(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-3)Gal(beta1-4)Gl c, Gal(alpha1-3)Gal(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-3)Gal(beta1-4)[F uc(alpha1-3)]Glc (difucosylheptasaccharide) and Gal(alpha1-3)Gal(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-3)¿Gal(alpha1-3) Gal(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-6)¿Gal(beta1-4)Glc (difucosyldecasaccharide). Lactose was present only in small amounts. Some of the milk oligosaccharides of the polar bear had alpha-Gal epitopes similar to some oligosaccharides in milk from the Ezo brown bear and the Japanese black bear. Some milk oligosaccharides had human blood group A antigens as well as B antigens; these were different from the oligosaccharides in Ezo brown and Japanese black bears.

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Year:  2000        PMID： 10913842     DOI： 10.1016/s0304-4165(00)00103-3

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  5 in total

1.  Chemical characterization of the milk oligosaccharides of some Artiodactyla species including giraffe (Giraffa camelopardalis), sitatunga (Tragelaphus spekii), deer (Cervus nippon yesoensis) and water buffalo (Bubalus bubalis).

Authors:  Yuri Mineguchi; Midori Miyoshi; Epi Taufik; Ayumi Kawamura; Takuya Asakawa; Isao Suzuki; Kousaku Souma; Michiko Okubo; Tadao Saito; Kenji Fukuda; Sadaki Asakuma; Tadasu Urashima
Journal:  Glycoconj J       Date:  2018-11-22       Impact factor: 2.916

Review 2.  Oligosaccharides of milk and colostrum in non-human mammals.

Authors:  T Urashima; T Saito; T Nakamura; M Messer
Journal:  Glycoconj J       Date:  2001-05       Impact factor: 2.916

3.  Chemical structures of oligosaccharides in milk of the raccoon (Procyon lotor).

Authors:  Tadasu Urashima; Emi Yamaguchi; Takeharu Ohshima; Kenji Fukuda; Tadao Saito
Journal:  Glycoconj J       Date:  2018-04-11       Impact factor: 2.916

4.  Chemical structures of oligosaccharides in milks of the American black bear (Ursus americanus americanus) and cheetah (Acinonyx jubatus).

Authors:  Tadasu Urashima; Masami Umewaki; Epi Taufik; Takeharu Ohshima; Kenji Fukuda; Tadao Saito; Katherine Whitehouse-Tedd; Jane A Budd; Olav T Oftedal
Journal:  Glycoconj J       Date:  2019-12-11       Impact factor: 2.916

5.  Changes in the Milk Metabolome of the Giant Panda (Ailuropoda melanoleuca) with Time after Birth--Three Phases in Early Lactation and Progressive Individual Differences.

Authors:  Tong Zhang; Rong Zhang; Liang Zhang; Zhihe Zhang; Rong Hou; Hairui Wang; I Kati Loeffler; David G Watson; Malcolm W Kennedy
Journal:  PLoS One       Date:  2015-12-02       Impact factor: 3.240
  5 in total

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