Nickel-catalyzed cyclizations, couplings, and cycloadditions involving three reactive components.

Transition-metal-catalyzed processes that allow the efficient coupling of three reactive components in a chemoselective and stereoselective fashion are particularly useful in the synthesis of complex organic molecules from simple, readily available substrates. This account outlines work primarily from the author's laboratory on the development of nickel-catalyzed multicomponent coupling processes. An overview of new synthetic methods, a discussion of potential mechanisms, and a description of applications in complex-molecule synthesis are provided.