Literature DB >> 10908346

The genes for small nucleolar RNAs in Trypanosoma brucei are organized in clusters and are transcribed as a polycistronic RNA.

D A Dunbar1, A A Chen, S Wormsley, S J Baserga.   

Abstract

Because the organization of snoRNA genes in vertebrates, plants and yeast is diverse, we investigated the organization of snoRNA genes in a distantly related organism, Trypanosoma brucei. We have characterized the second example of a snoRNA gene cluster that is tandemly repeated in the T.BRUCEI: genome. The genes encoding the box C/D snoRNAs TBR12, TBR6, TBR4 and TBR2 make up the cluster. In a genomic organization unique to trypanosomes, there are at least four clusters of these four snoRNA genes tandemly repeated in the T. BRUCEI: genome. We show for the first time that the genes encoding snoRNAs in both this cluster and the SLA cluster are transcribed in an unusual way as a polycistronic RNA.

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Year:  2000        PMID： 10908346      PMCID： PMC102681          DOI： 10.1093/nar/28.15.2855

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  43 in total

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Authors:  S Kass; K Tyc; J A Steitz; B Sollner-Webb
Journal:  Cell       Date:  1990-03-23       Impact factor: 41.582

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Authors:  I Cunningham
Journal:  J Protozool       Date:  1977-05

3.  Three small RNAs within the 10 kb trypanosome rRNA transcription unit are analogous to domain VII of other eukaryotic 28S rRNAs.

Authors:  T C White; G Rudenko; P Borst
Journal:  Nucleic Acids Res       Date:  1986-12-09       Impact factor: 16.971

4.  Precise identification of cleavage sites involved in the unusual processing of trypanosome ribosomal RNA.

Authors:  D A Campbell; K Kubo; C G Clark; J C Boothroyd
Journal:  J Mol Biol       Date:  1987-07-05       Impact factor: 5.469

5.  A small nucleolar RNA requirement for site-specific ribose methylation of rRNA in Xenopus.

Authors:  K T Tycowski; C M Smith; M D Shu; J A Steitz
Journal:  Proc Natl Acad Sci U S A       Date:  1996-12-10       Impact factor: 11.205

6.  The SLA RNA gene of Trypanosoma brucei is organized in a tandem array which encodes several small RNAs.

Authors:  T G Roberts; J M Dungan; K P Watkins; N Agabian
Journal:  Mol Biochem Parasitol       Date:  1996-12-20       Impact factor: 1.759

7.  A mammalian gene with introns instead of exons generating stable RNA products.

Authors:  K T Tycowski; M D Shu; J A Steitz
Journal:  Nature       Date:  1996-02-01       Impact factor: 49.962

8.  RNA polymerase III-mediated transcription of the trypanosome U2 small nuclear RNA gene is controlled by both intragenic and extragenic regulatory elements.

Authors:  A Fantoni; A O Dare; C Tschudi
Journal:  Mol Cell Biol       Date:  1994-03       Impact factor: 4.272

9.  Three small nucleolar RNAs identified from the spliced leader-associated RNA locus in kinetoplastid protozoans.

Authors:  T G Roberts; N R Sturm; B K Yee; M C Yu; T Hartshorne; N Agabian; D A Campbell
Journal:  Mol Cell Biol       Date:  1998-08       Impact factor: 4.272

10.  Depletion of U3 small nucleolar RNA inhibits cleavage in the 5' external transcribed spacer of yeast pre-ribosomal RNA and impairs formation of 18S ribosomal RNA.

Authors:  J M Hughes; M Ares
Journal:  EMBO J       Date:  1991-12       Impact factor: 11.598
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  17 in total

1.  Multiple snoRNA gene clusters from Arabidopsis.

Authors:  J W Brown; G P Clark; D J Leader; C G Simpson; T Lowe
Journal:  RNA       Date:  2001-12       Impact factor: 4.942

Review 2.  Life without transcriptional control? From fly to man and back again.

Authors:  Christine E Clayton
Journal:  EMBO J       Date:  2002-04-15       Impact factor: 11.598

3.  Novel non-coding RNAs in Dictyostelium discoideum and their expression during development.

Authors:  Anders Aspegren; Andrea Hinas; Pontus Larsson; Anders Larsson; Fredrik Söderbom
Journal:  Nucleic Acids Res       Date:  2004-08-27       Impact factor: 16.971

4.  A genome-wide analysis of C/D and H/ACA-like small nucleolar RNAs in Trypanosoma brucei reveals a trypanosome-specific pattern of rRNA modification.

Authors:  Xue-Hai Liang; Shai Uliel; Avraham Hury; Sarit Barth; Tirza Doniger; Ron Unger; Shulamit Michaeli
Journal:  RNA       Date:  2005-05       Impact factor: 4.942

5.  Elucidating the role of C/D snoRNA in rRNA processing and modification in Trypanosoma brucei.

Authors:  Sarit Barth; Boaz Shalem; Avraham Hury; Itai Dov Tkacz; Xue-Hai Liang; Shai Uliel; Inna Myslyuk; Tirza Doniger; Mali Salmon-Divon; Ron Unger; Shulamit Michaeli
Journal:  Eukaryot Cell       Date:  2007-11-02

6.  Identification of 10 novel snoRNA gene clusters from Arabidopsis thaliana.

Authors:  L H Qu; Q Meng; H Zhou; Y Q Chen; Q Liang-Hu; M Qing; Z Hui; C Yue-Qin
Journal:  Nucleic Acids Res       Date:  2001-04-01       Impact factor: 16.971

Review 7.  Cell biology of the trypanosome genome.

Authors:  Jan-Peter Daniels; Keith Gull; Bill Wickstead
Journal:  Microbiol Mol Biol Rev       Date:  2010-12       Impact factor: 11.056

8.  A novel class of developmentally regulated noncoding RNAs in Leishmania.

Authors:  Carole Dumas; Conan Chow; Michaela Müller; Barbara Papadopoulou
Journal:  Eukaryot Cell       Date:  2006-10-27

9.  The transcriptome of the human pathogen Trypanosoma brucei at single-nucleotide resolution.

Authors:  Nikolay G Kolev; Joseph B Franklin; Shai Carmi; Huafang Shi; Shulamit Michaeli; Christian Tschudi
Journal:  PLoS Pathog       Date:  2010-09-09       Impact factor: 6.823

10.  Pseudouridine-guide RNAs and other Cbf5p-associated RNAs in Euglena gracilis.

Authors:  Anthony G Russell; Murray N Schnare; Michael W Gray
Journal:  RNA       Date:  2004-07       Impact factor: 4.942
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