Literature DB >> 10903941

Novel cofactors via post-translational modifications of enzyme active sites.

N M Okeley1, W A van der Donk.   

Abstract

Recent crystallographic and biochemical studies have revealed the existence of numerous novel post-translational modifications within enzyme active sites. These modifications create structural and functional diversity. Although the function and biosynthesis of some of these modifications are well understood, others need further investigation.

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Year:  2000        PMID： 10903941     DOI： 10.1016/s1074-5521(00)00140-x

Source DB:  PubMed          Journal:  Chem Biol        ISSN： 1074-5521


  28 in total

1.  Crystal structure of the precursor of galactose oxidase: an unusual self-processing enzyme.

Authors:  S J Firbank; M S Rogers; C M Wilmot; D M Dooley; M A Halcrow; P F Knowles; M J McPherson; S E Phillips
Journal:  Proc Natl Acad Sci U S A       Date:  2001-11-06       Impact factor: 11.205

2.  Homemade cofactors: self-processing in galactose oxidase.

Authors:  L Xie; W A van der Donk
Journal:  Proc Natl Acad Sci U S A       Date:  2001-11-06       Impact factor: 11.205

3.  Evolutionary migration of a post-translationally modified active-site residue in the proton-pumping heme-copper oxygen reductases.

Authors:  James Hemp; Dana E Robinson; Krithika B Ganesan; Todd J Martinez; Neil L Kelleher; Robert B Gennis
Journal:  Biochemistry       Date:  2006-12-19       Impact factor: 3.162

Review 4.  Neurotoxicity in Alzheimer's disease: is covalently crosslinked A beta responsible?

Authors:  Ryan Naylor; Andrew F Hill; Kevin J Barnham
Journal:  Eur Biophys J       Date:  2007-12-07       Impact factor: 1.733

5.  Functional anthology of intrinsic disorder. 3. Ligands, post-translational modifications, and diseases associated with intrinsically disordered proteins.

Authors:  Hongbo Xie; Slobodan Vucetic; Lilia M Iakoucheva; Christopher J Oldfield; A Keith Dunker; Zoran Obradovic; Vladimir N Uversky
Journal:  J Proteome Res       Date:  2007-03-29       Impact factor: 4.466

6.  Structural basis for the retroreduction of inactivated peroxiredoxins by human sulfiredoxin.

Authors:  Thomas J Jönsson; Michael S Murray; Lynnette C Johnson; Leslie B Poole; W Todd Lowther
Journal:  Biochemistry       Date:  2005-06-21       Impact factor: 3.162

7.  Isotope labeling studies reveal the order of oxygen incorporation into the tryptophan tryptophylquinone cofactor of methylamine dehydrogenase.

Authors:  Arwen R Pearson; Sudha Marimanikkuppam; Xianghui Li; Victor L Davidson; Carrie M Wilmot
Journal:  J Am Chem Soc       Date:  2006-09-27       Impact factor: 15.419

8.  The stacking tryptophan of galactose oxidase: a second-coordination sphere residue that has profound effects on tyrosyl radical behavior and enzyme catalysis.

Authors:  Melanie S Rogers; Ejan M Tyler; Nana Akyumani; Christian R Kurtis; R Kate Spooner; Sarah E Deacon; Sarita Tamber; Susan J Firbank; Khaled Mahmoud; Peter F Knowles; Simon E V Phillips; Michael J McPherson; David M Dooley
Journal:  Biochemistry       Date:  2007-03-27       Impact factor: 3.162

Review 9.  Uncovering novel biochemistry in the mechanism of tryptophan tryptophylquinone cofactor biosynthesis.

Authors:  Carrie M Wilmot; Victor L Davidson
Journal:  Curr Opin Chem Biol       Date:  2009-08-03       Impact factor: 8.822

10.  Addition of the keto functional group to the genetic code of Escherichia coli.

Authors:  Lei Wang; Zhiwen Zhang; Ansgar Brock; Peter G Schultz
Journal:  Proc Natl Acad Sci U S A       Date:  2002-12-23       Impact factor: 11.205
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