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Literature DB >> 18064449

Neurotoxicity in Alzheimer's disease: is covalently crosslinked A beta responsible?

Ryan Naylor¹, Andrew F Hill, Kevin J Barnham.

Abstract

Alzheimer's disease is the most common form of dementia in the elderly, and is characterised by extracellular amyloid plaques composed of the beta-amyloid peptide (A beta). However, disease progression has been shown to correlate more closely with the level of soluble A beta oligomers. Recent evidence suggests that these oligomers are covalently crosslinked, possibly due to the interaction of A beta with redox-active metal ions. These findings offer new avenues for the treatment and prevention of disease, by modulating metal binding or preventing the formation of neurotoxic A beta oligomers.

Entities: Chemical Disease Gene

Mesh：

Substances：

Year: 2007 PMID： 18064449 DOI： 10.1007/s00249-007-0243-2

Source DB: PubMed Journal: Eur Biophys J ISSN： 0175-7571 Impact factor: 1.733

28 in total

1. Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease.

Authors: C A McLean; R A Cherny; F W Fraser; S J Fuller; M J Smith; K Beyreuther; A I Bush; C L Masters
Journal: Ann Neurol Date: 1999-12 Impact factor: 10.422

2. Protein crosslinking, tissue transglutaminase, alternative splicing and neurodegeneration.

Authors: Bruce A Citron; Zhiming Suo; Karen SantaCruz; Peter J A Davies; Frank Qin; Barry W Festoff
Journal: Neurochem Int Date: 2002-01 Impact factor: 3.921

3. A molecular switch in amyloid assembly: Met35 and amyloid beta-protein oligomerization.

Authors: Gal Bitan; Bogdan Tarus; Sabrina S Vollers; Hilal A Lashuel; Margaret M Condron; John E Straub; David B Teplow
Journal: J Am Chem Soc Date: 2003-12-17 Impact factor: 15.419

4. Amyloid-beta in Alzheimer disease: the null versus the alternate hypotheses.

Authors: Hyoung-gon Lee; Xiongwei Zhu; Rudy J Castellani; Akihiko Nunomura; George Perry; Mark A Smith
Journal: J Pharmacol Exp Ther Date: 2007-01-17 Impact factor: 4.030

5. Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins.

Authors: M P Lambert; A K Barlow; B A Chromy; C Edwards; R Freed; M Liosatos; T E Morgan; I Rozovsky; B Trommer; K L Viola; P Wals; C Zhang; C E Finch; G A Krafft; W L Klein
Journal: Proc Natl Acad Sci U S A Date: 1998-05-26 Impact factor: 11.205

6. Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils.

Authors: Aneta T Petkova; Richard D Leapman; Zhihong Guo; Wai-Ming Yau; Mark P Mattson; Robert Tycko
Journal: Science Date: 2005-01-14 Impact factor: 47.728

Review 7. Alois Alzheimer revisited: differences in origin of the disease carrying his name.

Authors: K Maurer; S Hoyer
Journal: J Neural Transm (Vienna) Date: 2006-10-23 Impact factor: 3.575

8. Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge.

Authors: David P Smith; Danielle G Smith; Cyril C Curtain; John F Boas; John R Pilbrow; Giuseppe D Ciccotosto; Tong-Lay Lau; Deborah J Tew; Keyla Perez; John D Wade; Ashley I Bush; Simon C Drew; Frances Separovic; Colin L Masters; Roberto Cappai; Kevin J Barnham
Journal: J Biol Chem Date: 2006-04-04 Impact factor: 5.157

Neurotoxicity in Alzheimer's disease: is covalently crosslinked A beta responsible?

1. Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease.

2. Protein crosslinking, tissue transglutaminase, alternative splicing and neurodegeneration.

3. A molecular switch in amyloid assembly: Met35 and amyloid beta-protein oligomerization.

4. Amyloid-beta in Alzheimer disease: the null versus the alternate hypotheses.

5. Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins.

6. Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils.

Review 7. Alois Alzheimer revisited: differences in origin of the disease carrying his name.

8. Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge.

9. Copper mediates dityrosine cross-linking of Alzheimer's amyloid-beta.

10. Cross-linking of beta-amyloid protein precursor catalyzed by tissue transglutaminase.

1. Beta-barrel models of soluble amyloid beta oligomers and annular protofibrils.

2. Interaction between amyloid-β pathology and cortical functional columnar organization.

3. The structure of the amyloid-beta peptide high-affinity copper II binding site in Alzheimer disease.

Review 4. Oxidized cholesterol as the driving force behind the development of Alzheimer's disease.

Review 5. Pharmacotherapeutic targets in Alzheimer's disease.

6. Structure-dependent effects of amyloid-β on long-term memory in Lymnaea stagnalis.