Literature DB >> 10902199

EDGAR: extraction of drugs, genes and relations from the biomedical literature.

T C Rindflesch1, L Tanabe, J N Weinstein, L Hunter.   

Abstract

EDGAR (Extraction of Drugs, Genes and Relations) is a natural language processing system that extracts information about drugs and genes relevant to cancer from the biomedical literature. This automatically extracted information has remarkable potential to facilitate computational analysis in the molecular biology of cancer, and the technology is straightforwardly generalizable to many areas of biomedicine. This paper reports on the mechanisms for automatically generating such assertions and on a simple application, conceptual clustering of documents. The system uses a stochastic part of speech tagger, generates an underspecified syntactic parse and then uses semantic and pragmatic information to construct its assertions. The system builds on two important existing resources: the MEDLINE database of biomedical citations and abstracts and the Unified Medical Language System, which provides syntactic and semantic information about the terms found in biomedical abstracts.

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Year:  2000        PMID: 10902199      PMCID: PMC2709525          DOI: 10.1142/9789814447331_0049

Source DB:  PubMed          Journal:  Pac Symp Biocomput        ISSN: 2335-6928


  11 in total

1.  Mining molecular binding terminology from biomedical text.

Authors:  T C Rindflesch; L Hunter; A R Aronson
Journal:  Proc AMIA Symp       Date:  1999

2.  An ontology for bioinformatics applications.

Authors:  P G Baker; C A Goble; S Bechhofer; N W Paton; R Stevens; A Brass
Journal:  Bioinformatics       Date:  1999-06       Impact factor: 6.937

3.  Constructing biological knowledge bases by extracting information from text sources.

Authors:  M Craven; J Kumlien
Journal:  Proc Int Conf Intell Syst Mol Biol       Date:  1999

4.  Developing NLP Tools for Genome Informatics: An Information Extraction Perspective.

Authors: 
Journal:  Genome Inform Ser Workshop Genome Inform       Date:  1998

5.  Detecting Gene Symbols and Names in Biological Texts: A First Step toward Pertinent Information Extraction.

Authors: 
Journal:  Genome Inform Ser Workshop Genome Inform       Date:  1998

6.  Automatic extraction of keywords from scientific text: application to the knowledge domain of protein families.

Authors:  M A Andrade; A Valencia
Journal:  Bioinformatics       Date:  1998       Impact factor: 6.937

7.  Toward information extraction: identifying protein names from biological papers.

Authors:  K Fukuda; A Tamura; T Tsunoda; T Takagi
Journal:  Pac Symp Biocomput       Date:  1998

8.  The Unified Medical Language System: an informatics research collaboration.

Authors:  B L Humphreys; D A Lindberg; H M Schoolman; G O Barnett
Journal:  J Am Med Inform Assoc       Date:  1998 Jan-Feb       Impact factor: 4.497

9.  Automatic construction of knowledge base from biological papers.

Authors:  Y Ohta; Y Yamamoto; T Okazaki; I Uchiyama; T Takagi
Journal:  Proc Int Conf Intell Syst Mol Biol       Date:  1997

10.  An information-intensive approach to the molecular pharmacology of cancer.

Authors:  J N Weinstein; T G Myers; P M O'Connor; S H Friend; A J Fornace; K W Kohn; T Fojo; S E Bates; L V Rubinstein; N L Anderson; J K Buolamwini; W W van Osdol; A P Monks; D A Scudiero; E A Sausville; D W Zaharevitz; B Bunow; V N Viswanadhan; G S Johnson; R E Wittes; K D Paull
Journal:  Science       Date:  1997-01-17       Impact factor: 47.728

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  69 in total

1.  Effective mapping of biomedical text to the UMLS Metathesaurus: the MetaMap program.

Authors:  A R Aronson
Journal:  Proc AMIA Symp       Date:  2001

Review 2.  An introduction to information retrieval: applications in genomics.

Authors:  P M Nadkarni
Journal:  Pharmacogenomics J       Date:  2002       Impact factor: 3.550

3.  NLP-based information extraction for managing the molecular biology literature.

Authors:  Bisharah Libbus; Thomas C Rindflesch
Journal:  Proc AMIA Symp       Date:  2002

4.  Research for research: tools for knowledge discovery and visualization.

Authors:  Erik M Van Mulligen; Christiaan Van Der Eijk; Jan A Kors; Bob J A Schijvenaars; Barend Mons
Journal:  Proc AMIA Symp       Date:  2002

5.  Semantic relations asserting the etiology of genetic diseases.

Authors:  Thomas C Rindflesch; Bisharah Libbus; Dimitar Hristovski; Alan R Aronson; Halil Kilicoglu
Journal:  AMIA Annu Symp Proc       Date:  2003

6.  Automated encoding of clinical documents based on natural language processing.

Authors:  Carol Friedman; Lyudmila Shagina; Yves Lussier; George Hripcsak
Journal:  J Am Med Inform Assoc       Date:  2004-06-07       Impact factor: 4.497

7.  Linguistic approach for identification of medication names and related information in clinical narratives.

Authors:  Thierry Hamon; Natalia Grabar
Journal:  J Am Med Inform Assoc       Date:  2010 Sep-Oct       Impact factor: 4.497

Review 8.  Natural Language Processing methods and systems for biomedical ontology learning.

Authors:  Kaihong Liu; William R Hogan; Rebecca S Crowley
Journal:  J Biomed Inform       Date:  2010-07-18       Impact factor: 6.317

9.  Automatic quality of life prediction using electronic medical records.

Authors:  Sergeui Pakhomov; Nilay Shah; Penny Hanson; Saranya Balasubramaniam; Steven A Smith; Steven Allan Smith
Journal:  AMIA Annu Symp Proc       Date:  2008-11-06

10.  Textpresso: an ontology-based information retrieval and extraction system for biological literature.

Authors:  Hans-Michael Müller; Eimear E Kenny; Paul W Sternberg
Journal:  PLoS Biol       Date:  2004-09-21       Impact factor: 8.029

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