Literature DB >> 10900380

Shunting is a translation strategy used by plant pararetroviruses (Caulimoviridae).

T Hohn1, S Corsten, D Dominguez, J Fütterer, D Kirk, M Hemmings-Mieszczak, M Pooggin, N Schärer-Hernandez, L Ryabova.   

Abstract

In eukaryotes standard initiation of translation involved 40S ribosome scanning to bridge the distance from the cap to the initiation codon. Recently deviations from that rule had been described, including "internal initiation", "poly-A dependent translation", and "ribosome shunting". In ribosome shunting, ribosomes start scanning at the cap but large portions of the leader are skipped. Thereby the secondary structure of the shunted region is preserved. Scanning in plant caulimoviruses involve a small open reading frame properly spaced in front of a strong stem structure, and, in order to function, the small open reading frome has to be translated and the peptide released. This arrangement can be mimicked by artificial small open reading frames and stem structures. Shunting with viral and synthetic leaders occurs not only in plant-, but also in mammalian and yeast systems. Thus it responds to an intrinsic property of the eukaryotic translational machinery and probably acts in many cases where coding regions are preceded by complex leaders.

Entities:  

Mesh:

Substances:

Year:  2001        PMID: 10900380     DOI: 10.1016/s0968-4328(00)00020-2

Source DB:  PubMed          Journal:  Micron        ISSN: 0968-4328            Impact factor:   2.251


  7 in total

Review 1.  Control of eukaryotic protein synthesis by upstream open reading frames in the 5'-untranslated region of an mRNA.

Authors:  Hedda A Meijer; Adri A M Thomas
Journal:  Biochem J       Date:  2002-10-01       Impact factor: 3.857

Review 2.  Host cell processes to accomplish mechanical and non-circulative virus transmission.

Authors:  Aurélie Bak; Sarah L Irons; Alexandre Martinière; Stéphane Blanc; Martin Drucker
Journal:  Protoplasma       Date:  2011-10-09       Impact factor: 3.356

3.  Mechanism of initiation site selection promoted by the human rhinovirus 2 internal ribosome entry site.

Authors:  Ann Kaminski; Tuija A A Pöyry; Peter J Skene; Richard J Jackson
Journal:  J Virol       Date:  2010-04-28       Impact factor: 5.103

4.  High frequency of alternative first exons in erythroid genes suggests a critical role in regulating gene function.

Authors:  Jeff S Tan; Narla Mohandas; John G Conboy
Journal:  Blood       Date:  2005-11-17       Impact factor: 22.113

5.  Unorthodox mRNA start site to extend the highly structured leader of retrotransposon Tto1 mRNA increases transposition rate.

Authors:  Gudrun Böhmdorfer; Ivo L Hofacker; Karin Garber; Srecko Jelenic; Viktoria Nizhynska; Hirohiko Hirochika; Peter F Stadler; Andreas Bachmair
Journal:  RNA       Date:  2005-08       Impact factor: 4.942

6.  Translation of cIAP2 mRNA is mediated exclusively by a stress-modulated ribosome shunt.

Authors:  Kyle W Sherrill; Richard E Lloyd
Journal:  Mol Cell Biol       Date:  2008-01-14       Impact factor: 4.272

Review 7.  Viral strategies of translation initiation: ribosomal shunt and reinitiation.

Authors:  Lyubov A Ryabova; Mikhail M Pooggin; Thomas Hohn
Journal:  Prog Nucleic Acid Res Mol Biol       Date:  2002
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.