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Literature DB >> 10900006

The serine and threonine residues in the Ig-alpha cytoplasmic tail negatively regulate immunoreceptor tyrosine-based activation motif-mediated signal transduction.

Abstract

The B cell antigen receptor (BCR) is a multiprotein complex consisting of the membrane-bound Ig molecule and the Ig-alpha/Ig-beta heterodimer. On BCR engagement, Ig-alpha and Ig-beta become phosphorylated not only on tyrosine residues of the immunoreceptor tyrosine-based activation motif but also on serine and threonine residues. We have mutated all serine and threonine residues in the Ig-alpha tail to alanine and valine, respectively. The mutated Ig-alpha sequence was expressed either as a single-chain Fv/Ig-alpha molecule or in the context of the complete BCR. In both cases, the mutated Ig-alpha showed a stronger tyrosine phosphorylation than the wild-type Ig-alpha and initiated increased signaling on stimulation. These findings suggest that serine/threonine kinases can negatively regulate signal transduction from the BCR.

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Year: 2000 PMID： 10900006 PMCID： PMC26968 DOI： 10.1073/pnas.97.15.8451

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

49 in total

1. Ig-alpha cytoplasmic truncation renders immature B cells more sensitive to antigen contact.

Authors: M Kraus; K Saijo; R M Torres; K Rajewsky
Journal: Immunity Date: 1999-11 Impact factor: 31.745

Review 2. G-protein coupled receptor kinases as modulators of G-protein signalling.

Authors: M Bünemann; M M Hosey
Journal: J Physiol Date: 1999-05-15 Impact factor: 5.182

3. Characterization of molecular components associated with surface immunoglobulin M in human B lymphocytes: presence of tyrosine and serine/threonine protein kinases.

Authors: C Leprince; K E Draves; J A Ledbetter; R M Torres; E A Clark
Journal: Eur J Immunol Date: 1992-08 Impact factor: 5.532

Review 4. The complexity of signaling pathways activated by the BCR.

Authors: A L DeFranco
Journal: Curr Opin Immunol Date: 1997-06 Impact factor: 7.486

5. In vitro characterization of major ligands for Src homology 2 domains derived from protein tyrosine kinases, from the adaptor protein SHC and from GTPase-activating protein in Ramos B cells.

Authors: G Baumann; D Maier; F Freuler; C Tschopp; K Baudisch; J Wienands
Journal: Eur J Immunol Date: 1994-08 Impact factor: 5.532

6. A tyrosine-based signal present in Ig alpha mediates B cell receptor constitutive internalization.

Authors: S Cassard; J Salamero; D Hanau; D Spehner; J Davoust; W H Fridman; C Bonnerot
Journal: J Immunol Date: 1998-02-15 Impact factor: 5.422

7. The alpha/beta sheath and its cytoplasmic tyrosines are required for signaling by the B-cell antigen receptor but not for capping or for serine/threonine-kinase recruitment.

Authors: G T Williams; C J Peaker; K J Patel; M S Neuberger
Journal: Proc Natl Acad Sci U S A Date: 1994-01-18 Impact factor: 11.205

8. Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli.

Authors: J S Huston; D Levinson; M Mudgett-Hunter; M S Tai; J Novotný; M N Margolies; R J Ridge; R E Bruccoleri; E Haber; R Crea
Journal: Proc Natl Acad Sci U S A Date: 1988-08 Impact factor: 11.205

9. Activation and serine phosphorylation of the p56lck protein tyrosine kinase in response to antigen receptor cross-linking in B lymphocytes.

Authors: M R Gold; R Chiu; R J Ingham; T M Saxton; I van Oostveen; J D Watts; M Affolter; R Aebersold
Journal: J Immunol Date: 1994-09-15 Impact factor: 5.422

10. A novel 34-kd protein co-isolated with the IgM molecule in surface IgM-expressing cells.

Authors: J Hombach; L Leclercq; A Radbruch; K Rajewsky; M Reth
Journal: EMBO J Date: 1988-11 Impact factor: 11.598

15 in total

Review 1. Ligand-independent signaling during early avian B cell development.

Authors: Kelly A Pike; Michael J H Ratcliffe
Journal: Immunol Res Date: 2006 Impact factor: 2.829

2. The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways.

Authors: Shara Kabak; Brian J Skaggs; Michael R Gold; Michael Affolter; Kelly L West; Mark S Foster; Karyn Siemasko; Andrew C Chan; Ruedi Aebersold; Marcus R Clark
Journal: Mol Cell Biol Date: 2002-04 Impact factor: 4.272

3. Dectin-1 intracellular domain determines species-specific ligand spectrum by modulating receptor sensitivity.

Authors: Tomotsugu Takano; Chihiro Motozono; Takashi Imai; Koh-Hei Sonoda; Yoichi Nakanishi; Sho Yamasaki
Journal: J Biol Chem Date: 2017-08-28 Impact factor: 5.157

4. The mouse B cell-specific mb-1 gene encodes an immunoreceptor tyrosine-based activation motif (ITAM) protein that may be evolutionarily conserved in diverse species by purifying selection.

Authors: Richard Sims; Virginia Oberholzer Vandergon; Cindy S Malone
Journal: Mol Biol Rep Date: 2011-06-19 Impact factor: 2.316

5. Cytoplasmic Ig alpha serine/threonines fine-tune Ig alpha tyrosine phosphorylation and limit bone marrow plasma cell formation.

Authors: Heide Christine Patterson; Manfred Kraus; Donghai Wang; Aliakbar Shahsafaei; Joel M Henderson; Jane Seagal; Kevin L Otipoby; To-Ha Thai; Klaus Rajewsky
Journal: J Immunol Date: 2011-08-12 Impact factor: 5.422