K L Margolis1, K E Ensrud, P J Schreiner, H K Tabor. 1. Division of Clinical Epidemiology, Hennepin County Medical Center, and School of Public Health, University of Minnesota, Minneapolis 55415, USA.
Abstract
BACKGROUND: Small body size predicts hip fractures in older women. OBJECTIVE: To test the hypothesis that small body size predicts the risk for other clinical fractures. DESIGN: Prospective cohort study. SETTING: Population-based listings in four areas of the United States. PATIENTS: 8059 ambulatory nonblack women 65 years of age or older. MEASUREMENTS: Weight, weight change since 25 years of age, body mass index, lean body mass and percent body fat, and nonspine fractures during 6.4 years of follow-up. RESULTS: Compared with women in the highest quartile of weight, women in the lowest quartile had relative risks of 2.0 (95% CI, 1.5 to 2.8) for hip fractures, 2.3 (CI, 1.1 to 4.7) for pelvis fractures, and 2.4 (CI, 1.5 to 3.9) for rib fractures. Adjustment for total-hip bone mineral density eliminated the elevated risk. Results were similar for other body size measures. Smaller body size was not a risk factor for humerus, elbow, wrist ankle, or foot fractures. CONCLUSIONS: Total body weight is useful in the prediction of hip, pelvis, and rib fractures when bone mineral density has not been measured.
BACKGROUND: Small body size predicts hip fractures in older women. OBJECTIVE: To test the hypothesis that small body size predicts the risk for other clinical fractures. DESIGN: Prospective cohort study. SETTING: Population-based listings in four areas of the United States. PATIENTS: 8059 ambulatory nonblack women 65 years of age or older. MEASUREMENTS: Weight, weight change since 25 years of age, body mass index, lean body mass and percent body fat, and nonspine fractures during 6.4 years of follow-up. RESULTS: Compared with women in the highest quartile of weight, women in the lowest quartile had relative risks of 2.0 (95% CI, 1.5 to 2.8) for hip fractures, 2.3 (CI, 1.1 to 4.7) for pelvis fractures, and 2.4 (CI, 1.5 to 3.9) for rib fractures. Adjustment for total-hip bone mineral density eliminated the elevated risk. Results were similar for other body size measures. Smaller body size was not a risk factor for humerus, elbow, wrist ankle, or foot fractures. CONCLUSIONS: Total body weight is useful in the prediction of hip, pelvis, and rib fractures when bone mineral density has not been measured.
Authors: D Prieto-Alhambra; F F Avilés; A Judge; T Van Staa; X Nogués; N K Arden; A Díez-Pérez; C Cooper; M K Javaid Journal: Osteoporos Int Date: 2012-02-04 Impact factor: 4.507
Authors: T K Omsland; B Schei; A B Grønskag; A Langhammer; L Forsén; C G Gjesdal; H E Meyer Journal: Osteoporos Int Date: 2009-03-07 Impact factor: 4.507