Literature DB >> 10893296

Role of telomerase in normal and cancer cells.

M Meyerson1.   

Abstract

Shortening of the telomeric DNA at chromosome ends is postulated to limit the lifespan of human cells. In contrast, activation of telomerase, the enzyme that synthesizes telomeric DNA, is proposed to be an essential step in cancer cell immortalization and cancer progression. This review discusses the structure and function of telomeres and telomerase, the role of telomerase in cell immortalization, and the effects of telomerase inactivation on normal and cancer cells. Moreover, data on the experimental use of telomerase assays for cancer detection and diagnosis are reviewed. Finally, the review considers the evidence regarding whether telomerase inhibitors could be used to treat human cancers.

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Year:  2000        PMID： 10893296     DOI： 10.1200/JCO.2000.18.13.2626

Source DB:  PubMed          Journal:  J Clin Oncol        ISSN： 0732-183X            Impact factor:   44.544


  37 in total

1.  Redundancy, antiredundancy, and the robustness of genomes.

Authors:  David C Krakauer; Joshua B Plotkin
Journal:  Proc Natl Acad Sci U S A       Date:  2002-01-29       Impact factor: 11.205

2.  Protein-RNA interaction restricts telomerase from running through the stop sign.

Authors:  Linghe Xi; Thomas R Cech
Journal:  Nat Struct Mol Biol       Date:  2015-11       Impact factor: 15.369

3.  The hTERT and hTERC telomerase gene promoters are activated by the second exon of the adenoviral protein, E1A, identifying the transcriptional corepressor CtBP as a potential repressor of both genes.

Authors:  Rosalind M Glasspool; Sharon Burns; Stacey F Hoare; Catharina Svensson; W Nicol Keith
Journal:  Neoplasia       Date:  2005-06       Impact factor: 5.715

4.  Mesenchymal stem cell and nucleus pulposus cell coculture modulates cell profile.

Authors:  Chi-Chien Niu; Li-Jen Yuan; Song-Shu Lin; Lih-Huei Chen; Wen-Jer Chen
Journal:  Clin Orthop Relat Res       Date:  2008-11-26       Impact factor: 4.176

5.  Differential cis-regulation of human versus mouse TERT gene expression in vivo: identification of a human-specific repressive element.

Authors:  Izumi Horikawa; Y Jeffrey Chiang; Tricia Patterson; Lionel Feigenbaum; Sun-Hee Leem; Eriko Michishita; Vladimir Larionov; Richard J Hodes; J Carl Barrett
Journal:  Proc Natl Acad Sci U S A       Date:  2005-12-12       Impact factor: 11.205

6.  Clinical significance of hTERC gene amplification detection by FISH in the screening of cervical lesions.

Authors:  Yuan Zhang; Xiaobei Wang; Ling Ma; Zehua Wang; Lihua Hu
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2009-06-10

7.  Short rare hTERT-VNTR2-2nd alleles are associated with prostate cancer susceptibility and influence gene expression.

Authors:  Se-Lyun Yoon; Se-Il Jung; Eun-Ju Do; Se-Ra Lee; Sang-Yeop Lee; In-Sun Chu; Wun-Jae Kim; Jaeil Jung; Choung Soo Kim; Sang-Hyeon Cheon; Sun-Hee Leem
Journal:  BMC Cancer       Date:  2010-07-26       Impact factor: 4.430

8.  Association of telomerase activity with radio- and chemosensitivity of neuroblastomas.

Authors:  Simone Wesbuer; Claudia Lanvers-Kaminsky; Ines Duran-Seuberth; Tobias Bölling; Karl-Ludwig Schäfer; Yvonne Braun; Normann Willich; Burkhard Greve
Journal:  Radiat Oncol       Date:  2010-07-19       Impact factor: 3.481

Review 9.  A translational bridge to cancer immunotherapy: exploiting costimulation and target antigens for active and passive T cell immunotherapy.

Authors:  Robert H Vonderheide; Carl H June
Journal:  Immunol Res       Date:  2003       Impact factor: 2.829

10.  Expression of telomerase and telomere length are unaffected by either age or limb regeneration in Danio rerio.

Authors:  Troy C Lund; Tiffany J Glass; Jakub Tolar; Bruce R Blazar
Journal:  PLoS One       Date:  2009-11-06       Impact factor: 3.240
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