T Blekher1, E Siemers, L A Abel, R D Yee. 1. Department of Ophthalmology, Indiana University School of Medicine, Indianapolis 46202-5175, USA.
Abstract
PURPOSE: To evaluate the effects of unilateral, stereotactic, posteroventral pallidotomy on saccadic eye movements in patients with Parkinson disease (PD). METHODS: Eye movements of 31 patients with moderate to advanced PD were recorded with an infrared system 1 month before and 3 months after pallidotomy. Two kinds of saccade tasks were used: saccade tasks for eliciting visually guided saccades and saccade tasks for eliciting internally mediated saccades (memory-guided, predictive, and anti-saccades). Latency, accuracy, peak velocity, and other parameters of saccades were evaluated. RESULTS: Internally mediated saccades were more impaired in patients with advanced PD compared with those with moderate PD. Pallidotomy did not affect visually guided saccades. After pallidotomy, the peak saccadic velocity of internally mediated saccades decreased. CONCLUSIONS: Hence, although pallidotomy has led to improvements in other motor functions, none were observed in saccadic responses. Rather, several modest decrements, below the level of clinical significance and all in internally mediated saccades, were observed.
PURPOSE: To evaluate the effects of unilateral, stereotactic, posteroventral pallidotomy on saccadic eye movements in patients with Parkinson disease (PD). METHODS: Eye movements of 31 patients with moderate to advanced PD were recorded with an infrared system 1 month before and 3 months after pallidotomy. Two kinds of saccade tasks were used: saccade tasks for eliciting visually guided saccades and saccade tasks for eliciting internally mediated saccades (memory-guided, predictive, and anti-saccades). Latency, accuracy, peak velocity, and other parameters of saccades were evaluated. RESULTS: Internally mediated saccades were more impaired in patients with advanced PD compared with those with moderate PD. Pallidotomy did not affect visually guided saccades. After pallidotomy, the peak saccadic velocity of internally mediated saccades decreased. CONCLUSIONS: Hence, although pallidotomy has led to improvements in other motor functions, none were observed in saccadic responses. Rather, several modest decrements, below the level of clinical significance and all in internally mediated saccades, were observed.
Authors: Chrystalina A Antoniades; Pedro Rebelo; Christopher Kennard; Tipu Z Aziz; Alexander L Green; James J FitzGerald Journal: J Neurosci Date: 2015-09-23 Impact factor: 6.167
Authors: Tomáš Sieger; Cecilia Bonnet; Tereza Serranová; Jiří Wild; Daniel Novák; Filip Růžička; Dušan Urgošík; Evžen Růžička; Bertrand Gaymard; Robert Jech Journal: PLoS One Date: 2013-11-06 Impact factor: 3.240