STUDY OBJECTIVE: To determine whether long term weight gain and weight loss are associated with subsequent risk of type 2 diabetes in overweight, non-diabetic adults. DESIGN: Prospective cohort. Baseline overweight was defined as BMI>/=27.3 for women and BMI>/=27. 8 for men. Annual weight change (kg/year) over 10 years was calculated using measured weight at subjects' baseline and first follow up examinations. In the 10 years after measurement of weight change, incident cases of diabetes were ascertained by self report, hospital discharge records, and death certificates. SETTING: Community. PARTICIPANTS: 1929 overweight, non-diabetic adults. MAIN RESULTS: Incident diabetes was ascertained in 251 subjects. Age adjusted cumulative incidence increased from 9.6% for BMI<29 to 26. 2% for BMI>/=37. Annual weight change over 10 years was higher in subjects who become diabetic compared with those who did not for all BMI<35. Relative to overweight people with stable weight, each kg of weight gained annually over 10 years was associated with a 49% increase in risk of developing diabetes in the subsequent 10 years. Each kg of weight lost annually over 10 years was associated with a 33% lower risk of diabetes in the subsequent 10 years. CONCLUSIONS: Weight gain was associated with substantially increased risk of diabetes among overweight adults, and even modest weight loss was associated with significantly reduced diabetes risk. Minor weight reductions may have major beneficial effects on subsequent diabetes risk in overweight adults at high risk of developing diabetes.
STUDY OBJECTIVE: To determine whether long term weight gain and weight loss are associated with subsequent risk of type 2 diabetes in overweight, non-diabetic adults. DESIGN: Prospective cohort. Baseline overweight was defined as BMI>/=27.3 for women and BMI>/=27. 8 for men. Annual weight change (kg/year) over 10 years was calculated using measured weight at subjects' baseline and first follow up examinations. In the 10 years after measurement of weight change, incident cases of diabetes were ascertained by self report, hospital discharge records, and death certificates. SETTING: Community. PARTICIPANTS: 1929 overweight, non-diabetic adults. MAIN RESULTS: Incident diabetes was ascertained in 251 subjects. Age adjusted cumulative incidence increased from 9.6% for BMI<29 to 26. 2% for BMI>/=37. Annual weight change over 10 years was higher in subjects who become diabetic compared with those who did not for all BMI<35. Relative to overweight people with stable weight, each kg of weight gained annually over 10 years was associated with a 49% increase in risk of developing diabetes in the subsequent 10 years. Each kg of weight lost annually over 10 years was associated with a 33% lower risk of diabetes in the subsequent 10 years. CONCLUSIONS:Weight gain was associated with substantially increased risk of diabetes among overweight adults, and even modest weight loss was associated with significantly reduced diabetes risk. Minor weight reductions may have major beneficial effects on subsequent diabetes risk in overweight adults at high risk of developing diabetes.
Authors: Y Sakurai; K Teruya; N Shimada; K Wakabayashi; T Umeda; S Honjo; I Todoroki; H Tanaka; T Muto; M Sakurai; K Nakamura Journal: Diabetes Care Date: 1997-06 Impact factor: 19.112
Authors: J H Madans; J C Kleinman; C S Cox; H E Barbano; J J Feldman; B Cohen; F F Finucane; J Cornoni-Huntley Journal: Public Health Rep Date: 1986 Sep-Oct Impact factor: 2.792
Authors: R L Hanson; K M Narayan; D R McCance; D J Pettitt; L T Jacobsson; P H Bennett; W C Knowler Journal: Diabetes Date: 1995-03 Impact factor: 9.461
Authors: Barbara A Ormond; Brenda C Spillman; Timothy A Waidmann; Kyle J Caswell; Bogdan Tereshchenko Journal: Am J Public Health Date: 2010-11-18 Impact factor: 9.308
Authors: Ashok Krishnaswami; Rohini Ashok; Stephen Sidney; Michael Okimura; Beth Kramer; Lindsey Hogan; Michael Sorel; Sheri Pruitt; Wayne Smith Journal: Perm J Date: 2018
Authors: Mark S Nash; Suzanne L Groah; David R Gater; Trevor A Dyson-Hudson; Jesse A Lieberman; Jonathan Myers; Sunil Sabharwal; Allen J Taylor Journal: J Spinal Cord Med Date: 2019-06-10 Impact factor: 1.985
Authors: Mark S Nash; Suzanne L Groah; David R Gater; Trevor A Dyson-Hudson; Jesse A Lieberman; Jonathan Myers; Sunil Sabharwal; Allen J Taylor Journal: Top Spinal Cord Inj Rehabil Date: 2018
Authors: Michelle C Kegler; Iris Alcantara; J K Veluswamy; Regine Haardörfer; James A Hotz; Karen Glanz Journal: Prog Community Health Partnersh Date: 2012
Authors: Merja Kataja-Tuomola; Jari Sundell; Satu Männistö; Mikko J Virtanen; Jukka Kontto; Demetrius Albanes; Jarmo Virtamo Journal: Eur J Epidemiol Date: 2010-03-30 Impact factor: 8.082
Authors: Amy M Berkman; Amy Trentham-Dietz; Kim Dittus; Vicki Hart; Christine M Vatovec; John G King; Ted A James; Susan G Lakoski; Brian L Sprague Journal: Prev Med Date: 2015-04-06 Impact factor: 4.018