| Literature DB >> 10889556 |
M G McInnis1, T Swift-Scanlanl, A T Mahoney, J Vincent, G Verheyen, T H Lan, L Oruc, O Riess, C Van Broeckhoven, H Chen, J L Kennedy, D F MacKinnon, R L Margolis, S G Simpson, F J McMahon, E Gershon, J Nurnberger, T Reich, J R DePaulo, C A Ross.
Abstract
CTG18.1 is a highly polymorphic and unstable CTG repeat within an intron of the SEF2-1 gene. We tested the CTG18.1 repeat length in affective disorder, schizophrenia, and nonspecific ataxia; these diseases all have shown clinical evidence for anticipation. There was no difference in the allele frequencies comparing the controls and disease groups. The most common allele contains 11 CAGs (35%) followed by alleles with 14-17 CAGs (35%). There was no difference in the distribution of the alleles in the cases vs controls for ataxia (P = 0.11), affective disorders (P = 0.21), or schizophrenia (P = 0.26). The frequency of unstable CTG18.1 alleles was approximately 3% in a population of N. European descent and is not related to the phenotypes tested.Entities:
Mesh：
Substances：
Year: 2000 PMID： 10889556 DOI： 10.1038/sj.mp.4000747
Source DB: PubMed Journal: Mol Psychiatry ISSN： 1359-4184 Impact factor: 15.992