BACKGROUND: Altered heart and skeletal glucose usage has been reported in patients with non-insulin-dependent diabetes mellitus (NIDDM). Although elevations in plasma free fatty acid (FFA) concentrations have been implicated in reduced myocardial 18fluorine-fluoro-2-deoxy-D-glucose uptake (MFU), the specific role of whole-body insulin resistance in MFU in patients with NIDDM compared with skeletal muscle metabolism remains controversial. PURPOSE: MFU and skeletal muscle 18fluorine-fluoro-2-deoxy-D-glucose uptake (SMFU) were compared with positron emission tomography and the whole-body glucose disposal rate (GDR) during hyperinsulinemic euglycemic clamping in 26 normotensive asymptomatic patients with NIDDM who were not taking medication. These factors were also compared in 12 age-matched control subjects to increase the knowledge of the influence of whole-body insulin resistance on MFU. In addition, independent factors for both SMFU and MFU were investigated. RESULTS: GDR in control subjects (10.0 +/- 2.97 mg/min per kilogram) was significantly higher than in patients with NIDDM (4.05 +/- 2.37 mg/min per kilogram, P < .01). SMFU in patients with NIDDM (0.826 +/- 0.604 mg/min per 100 g) was significantly lower than that in control subjects (1.86 +/- 1.06 mg/min per 100 g, P < .01). MFU in patients with NIDDM (5.35 +/- 2.10 mg/min per 100 g) was also significantly lower than that of control subjects (7.05 +/- 1.66 mg/min per 100 g, P = .0182). SMFU significantly correlated with GDR (r = .727, P < .01) and FFA (r = -.52, P < .01) in patients with NIDDM. MFU also correlated with GDR (r = .778, P < .01) and FFA (r = -.72, P < .01) in patients with NIDDM. Multivariate stepwise regression analysis showed that GDR (F = 36.8) was independently related to MFU (r = .85, P < .01) whereas FFA was not (F = 1.763), where F is the value for statistical analysis of multivariate stepwise regression analysis. CONCLUSION: Insulin resistance is the most essential factor for both heart and skeletal muscle FDG uptake in patients with NIDDM.
BACKGROUND: Altered heart and skeletal glucose usage has been reported in patients with non-insulin-dependent diabetes mellitus (NIDDM). Although elevations in plasma free fatty acid (FFA) concentrations have been implicated in reduced myocardial 18fluorine-fluoro-2-deoxy-D-glucose uptake (MFU), the specific role of whole-body insulin resistance in MFU in patients with NIDDM compared with skeletal muscle metabolism remains controversial. PURPOSE: MFU and skeletal muscle 18fluorine-fluoro-2-deoxy-D-glucose uptake (SMFU) were compared with positron emission tomography and the whole-body glucose disposal rate (GDR) during hyperinsulinemic euglycemic clamping in 26 normotensive asymptomatic patients with NIDDM who were not taking medication. These factors were also compared in 12 age-matched control subjects to increase the knowledge of the influence of whole-body insulin resistance on MFU. In addition, independent factors for both SMFU and MFU were investigated. RESULTS:GDR in control subjects (10.0 +/- 2.97 mg/min per kilogram) was significantly higher than in patients with NIDDM (4.05 +/- 2.37 mg/min per kilogram, P < .01). SMFU in patients with NIDDM (0.826 +/- 0.604 mg/min per 100 g) was significantly lower than that in control subjects (1.86 +/- 1.06 mg/min per 100 g, P < .01). MFU in patients with NIDDM (5.35 +/- 2.10 mg/min per 100 g) was also significantly lower than that of control subjects (7.05 +/- 1.66 mg/min per 100 g, P = .0182). SMFU significantly correlated with GDR (r = .727, P < .01) and FFA (r = -.52, P < .01) in patients with NIDDM. MFU also correlated with GDR (r = .778, P < .01) and FFA (r = -.72, P < .01) in patients with NIDDM. Multivariate stepwise regression analysis showed that GDR (F = 36.8) was independently related to MFU (r = .85, P < .01) whereas FFA was not (F = 1.763), where F is the value for statistical analysis of multivariate stepwise regression analysis. CONCLUSION:Insulin resistance is the most essential factor for both heart and skeletal muscle FDG uptake in patients with NIDDM.
Authors: H E Bøtker; M Böttcher; O Schmitz; A Gee; S B Hansen; G E Cold; T T Nielsen; A Gjedde Journal: J Nucl Cardiol Date: 1997 Mar-Apr Impact factor: 5.952
Authors: P Nuutila; V A Koivisto; J Knuuti; U Ruotsalainen; M Teräs; M Haaparanta; J Bergman; O Solin; L M Voipio-Pulkki; U Wegelius Journal: J Clin Invest Date: 1992-06 Impact factor: 14.808
Authors: P Casassus; A Fontbonne; N Thibult; P Ducimetière; J L Richard; J R Claude; J M Warnet; G Rosselin; E Eschwège Journal: Arterioscler Thromb Date: 1992-12
Authors: J P Després; B Lamarche; P Mauriège; B Cantin; G R Dagenais; S Moorjani; P J Lupien Journal: N Engl J Med Date: 1996-04-11 Impact factor: 91.245
Authors: Janet B McGill; Linda R Peterson; Pilar Herrero; Ibrahim M Saeed; Carol Recklein; Andrew R Coggan; Amanda J Demoss; Kenneth B Schechtman; Carmen S Dence; Robert J Gropler Journal: J Nucl Cardiol Date: 2011-04-23 Impact factor: 5.952
Authors: Darren C Henstridge; E Estevez; T L Allen; S E Heywood; T Gardner; C Yang; N A Mellett; B A Kingwell; P J Meikle; M A Febbraio Journal: Cell Stress Chaperones Date: 2015-01-25 Impact factor: 3.667
Authors: Elena Succurro; Patrizia Vizza; Annalisa Papa; Francesco Cicone; Giuseppe Monea; Giuseppe Tradigo; Teresa Vanessa Fiorentino; Maria Perticone; Pietro Hiram Guzzi; Angela Sciacqua; Francesco Andreozzi; Pierangelo Veltri; Giuseppe Lucio Cascini; Giorgio Sesti Journal: Front Cardiovasc Med Date: 2022-06-29
Authors: K J Mather; G D Hutchins; K Perry; W Territo; R Chisholm; A Acton; B Glick-Wilson; R V Considine; S Moberly; T R DeGrado Journal: Am J Physiol Endocrinol Metab Date: 2016-01-05 Impact factor: 4.310
Authors: Jan Hansen; Birgitte Brock; Hans Erik Bøtker; Albert Gjedde; Jørgen Rungby; Michael Gejl Journal: Rev Endocr Metab Disord Date: 2014-09 Impact factor: 6.514
Authors: Marja A Heiskanen; Tanja J Sjöros; Ilkka H A Heinonen; Eliisa Löyttyniemi; Mikko Koivumäki; Kumail K Motiani; Jari-Joonas Eskelinen; Kirsi A Virtanen; Juhani Knuuti; Jarna C Hannukainen; Kari K Kalliokoski Journal: Sci Rep Date: 2017-09-05 Impact factor: 4.379