Literature DB >> 10882096

Identification and characterization of a novel cell cycle-regulated internal ribosome entry site.

S Cornelis1, Y Bruynooghe, G Denecker, S Van Huffel, S Tinton, R Beyaert.   

Abstract

PITSLRE protein kinases are related to the large family of cyclin-dependent kinases. They have been proposed to act as tumor suppressor genes and have been shown to play a role in cell cycle progression. We report that two PITSLRE protein kinase isoforms, namely p11O(PITSLRE) and p58(PITSLRE), are translated from a single transcript by initiation at alternative in-frame AUG codons. p110(PITSLRE) is produced by classical cap-dependent translation, whereas p58(PITSLRE) results from internal initiation of translation controlled by an internal ribosome entry site (IRES) with unique properties. The IRES element is localized to the mRNA coding region, and its activity is cell cycle regulated, which permits translation of p58(PITSLRE) in G2/M.

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Year:  2000        PMID： 10882096     DOI： 10.1016/s1097-2765(00)80239-7

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  135 in total

Review 1.  Recognition of nascent RNA by the human La antigen: conserved and divergent features of structure and function.

Authors:  R J Maraia; R V Intine
Journal:  Mol Cell Biol       Date:  2001-01       Impact factor: 4.272

2.  Identification of two short internal ribosome entry sites selected from libraries of random oligonucleotides.

Authors:  G C Owens; S A Chappell; V P Mauro; G M Edelman
Journal:  Proc Natl Acad Sci U S A       Date:  2001-02-13       Impact factor: 11.205

Review 3.  New ways of initiating translation in eukaryotes?

Authors:  M Kozak
Journal:  Mol Cell Biol       Date:  2001-03       Impact factor: 4.272

4.  New ways of initiating translation in eukaryotes.

Authors:  R Schneider; V I Agol; R Andino; F Bayard; D R Cavener; S A Chappell; J J Chen; J L Darlix; A Dasgupta; O Donzé; R Duncan; O Elroy-Stein; P J Farabaugh; W Filipowicz; M Gale; L Gehrke; E Goldman; Y Groner; J B Harford; M Hatzglou; B He; C U Hellen; M W Hentze; J Hershey; P Hershey; T Hohn; M Holcik; C P Hunter; K Igarashi; R Jackson; R Jagus; L S Jefferson; B Joshi; R Kaempfer; M Katze; R J Kaufman; M Kiledjian; S R Kimball; A Kimchi; K Kirkegaard; A E Koromilas; R M Krug; V Kruys; B J Lamphear; S Lemon; R E Lloyd; L E Maquat; E Martinez-Salas; M B Mathews; V P Mauro; S Miyamoto; I Mohr; D R Morris; E G Moss; N Nakashima; A Palmenberg; N T Parkin; T Pe'ery; J Pelletier; S Peltz; T V Pestova; E V Pilipenko; A C Prats; V Racaniello; G S Read; R E Rhoads; J D Richter; R Rivera-Pomar; T Rouault; A Sachs; P Sarnow; G C Scheper; L Schiff; D R Schoenberg; B L Semler; A Siddiqui; T Skern; N Sonenberg; W Sossin; N Standart; S M Tahara; A A Thomas; J J Toulmé; J Wilusz; E Wimmer; G Witherell; M Wormington
Journal:  Mol Cell Biol       Date:  2001-12       Impact factor: 4.272

5.  La autoantigen enhances translation of BiP mRNA.

Authors:  Y K Kim; S H Back; J Rho; S H Lee; S K Jang
Journal:  Nucleic Acids Res       Date:  2001-12-15       Impact factor: 16.971

6.  Unleashing yeast genetics on a factor-independent mechanism of internal translation initiation.

Authors:  A G Hinnebusch
Journal:  Proc Natl Acad Sci U S A       Date:  2001-11-06       Impact factor: 11.205

Review 7.  Irresistible IRES. Attracting the translation machinery to internal ribosome entry sites.

Authors:  S Vagner; B Galy; S Pyronnet
Journal:  EMBO Rep       Date:  2001-10       Impact factor: 8.807

8.  A cell cycle-dependent protein serves as a template-specific translation initiation factor.

Authors:  E V Pilipenko; T V Pestova; V G Kolupaeva; E V Khitrina; A N Poperechnaya; V I Agol; C U Hellen
Journal:  Genes Dev       Date:  2000-08-15       Impact factor: 11.361

9.  Rous sarcoma virus translation revisited: characterization of an internal ribosome entry segment in the 5' leader of the genomic RNA.

Authors:  C Deffaud; J L Darlix
Journal:  J Virol       Date:  2000-12       Impact factor: 5.103

10.  CDK11(p58) kinase activity is required to protect sister chromatid cohesion at centromeres in mitosis.

Authors:  Tarik Rakkaa; Christophe Escudé; Régis Giet; Laura Magnaghi-Jaulin; Christian Jaulin
Journal:  Chromosome Res       Date:  2014-01-17       Impact factor: 5.239
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