Literature DB >> 10878813

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

A Herreman1, L Serneels, W Annaert, D Collen, L Schoonjans, B De Strooper.   

Abstract

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Year:  2000        PMID： 10878813     DOI： 10.1038/35017105

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


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  135 in total

1.  spr-2, a suppressor of the egg-laying defect caused by loss of sel-12 presenilin in Caenorhabditis elegans, is a member of the SET protein subfamily.

Authors:  C Wen; D Levitan; X Li; I Greenwald
Journal:  Proc Natl Acad Sci U S A       Date:  2000-12-19       Impact factor: 11.205

2.  Presenilin-dependent gamma-secretase activity modulates thymocyte development.

Authors:  P Doerfler; M S Shearman; R M Perlmutter
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-24       Impact factor: 11.205

3.  Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate.

Authors:  William P Esler; W Taylor Kimberly; Beth L Ostaszewski; Wenjuan Ye; Thekla S Diehl; Dennis J Selkoe; Michael S Wolfe
Journal:  Proc Natl Acad Sci U S A       Date:  2002-02-26       Impact factor: 11.205

4.  The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling.

Authors:  Roberta Roncarati; Nenad Sestan; Meir H Scheinfeld; Bridget E Berechid; Peter A Lopez; Olimpia Meucci; Jane C McGlade; Pasko Rakic; Luciano D'Adamio
Journal:  Proc Natl Acad Sci U S A       Date:  2002-05-14       Impact factor: 11.205

5.  Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation.

Authors:  Dieter Edbauer; Edith Winkler; Christian Haass; Harald Steiner
Journal:  Proc Natl Acad Sci U S A       Date:  2002-06-04       Impact factor: 11.205

6.  Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype.

Authors:  Richard Rozmahel; Howard T J Mount; Fusheng Chen; Van Nguyen; Jean Huang; Serap Erdebil; Jennifer Liauw; Gang Yu; Hiroshe Hasegawa; YongJun Gu; You-Qiang Song; Stephen D Schmidt; Ralph A Nixon; Paul M Mathews; Catherine Bergeron; Paul Fraser; David Westaway; Peter St George-Hyslop
Journal:  Proc Natl Acad Sci U S A       Date:  2002-10-18       Impact factor: 11.205

Review 7.  Deciphering the genesis and fate of amyloid beta-protein yields novel therapies for Alzheimer disease.

Authors:  Dennis J Selkoe
Journal:  J Clin Invest       Date:  2002-11       Impact factor: 14.808

8.  A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish.

Authors:  Andrea Geling; Harald Steiner; Michael Willem; Laure Bally-Cuif; Christian Haass
Journal:  EMBO Rep       Date:  2002-07       Impact factor: 8.807

9.  Syntaxin 5 interacts with presenilin holoproteins, but not with their N- or C-terminal fragments, and affects beta-amyloid peptide production.

Authors:  Kei Suga; Takami Tomiyama; Hiroshi Mori; Kimio Akagawa
Journal:  Biochem J       Date:  2004-08-01       Impact factor: 3.857

10.  Presenilin 1 affects focal adhesion site formation and cell force generation via c-Src transcriptional and posttranslational regulation.

Authors:  Dieter Waschbüsch; Simone Born; Verena Niediek; Norbert Kirchgessner; Irfan Y Tamboli; Jochen Walter; Rudolf Merkel; Bernd Hoffmann
Journal:  J Biol Chem       Date:  2009-01-27       Impact factor: 5.157
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