| Literature DB >> 10877537 |
M Uchida1, Y Kato, K Matsueda, R Shoda, A Muraoka, S Yamato.
Abstract
Nitric oxide (NO) is involved in the mechanism of castor oil-induced diarrhea. This study was performed to elucidate the source of NO. Diarrhea was induced by oral administration of castor oil in rats. Diarrhea was significantly inhibited by the pre-treatment with a relatively selective nerve NO synthase inhibitor, 7-nitroindazole. This effect was attenuated by the treatment with L-arginine. Capsaicin-sensitive afferent nerve degeneration did not affect the diarrhea. N(G)-Nitro-L-arginine methylester significantly inhibited diarrhea even in capsaicin-pretreated rats. These data suggest, at least in part, the involvement of NO from nerves on the diarrhea induced by castor oil in rats.Entities:
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Year: 2000 PMID： 10877537 DOI： 10.1254/jjp.82.168
Source DB: PubMed Journal: Jpn J Pharmacol ISSN： 0021-5198