Literature DB >> 10867750

Is autism a G-alpha protein defect reversible with natural vitamin A?

M N Megson1.   

Abstract

Autism may be a disorder linked to the disruption of the G-alpha protein, affecting retinoid receptors in the brain. A study of 60 autistic children suggests that autism may be caused by inserting a G-alpha protein defect, the pertussis toxin found in the DPT vaccine, into genetically at-risk children. This toxin separates the G-alpha protein from retinoid receptors. Those most at risk report a family history of at least one parent with a pre-existing G-alpha protein defect, including night blindness, pseudohypoparathyroidism or adenoma of the thyroid or pituitary gland. Natural vitamin A may reconnect the retinoid receptors critical for vision, sensory perception, language processing and attention. Autism spectrum disorders have increased from 1 in 10 000 in 1978 to 1 in 300 in some US communities in 1999. Recent evidence indicates that autism is a disorder of the nervous system and the immune system, affecting multiple metabolic pathways.

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Year:  2000        PMID: 10867750     DOI: 10.1054/mehy.1999.0999

Source DB:  PubMed          Journal:  Med Hypotheses        ISSN: 0306-9877            Impact factor:   1.538


  11 in total

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Authors:  A P Dubey; S Banerjee
Journal:  Indian J Pediatr       Date:  2003-07       Impact factor: 1.967

2.  Modular patterning of structure and function of the striatum by retinoid receptor signaling.

Authors:  Wen-Lin Liao; Hsiu-Chao Tsai; Hsiao-Fang Wang; Josephine Chang; Kuan-Ming Lu; Hsiao-Lin Wu; Yi-Chao Lee; Ting-Fen Tsai; Hiroshi Takahashi; Michael Wagner; Norbert B Ghyselinck; Pierre Chambon; Fu-Chin Liu
Journal:  Proc Natl Acad Sci U S A       Date:  2008-04-28       Impact factor: 11.205

3.  Immunization and children at risk for autism.

Authors:  Wendy Roberts; Mary Harford
Journal:  Paediatr Child Health       Date:  2002-11       Impact factor: 2.253

4.  Case of hypercalcemia secondary to hypervitaminosis a in a 6-year-old boy with autism.

Authors:  Arpita Kalla Vyas; Neil H White
Journal:  Case Rep Endocrinol       Date:  2011-09-11

5.  Effect of vitamin A supplementation on gut microbiota in children with autism spectrum disorders - a pilot study.

Authors:  Juan Liu; Xiao Liu; Xue-Qin Xiong; Ting Yang; Ting Cui; Na-Li Hou; Xi Lai; Shu Liu; Min Guo; Xiao-Hua Liang; Qian Cheng; Jie Chen; Ting-Yu Li
Journal:  BMC Microbiol       Date:  2017-09-22       Impact factor: 3.605

Review 6.  Relationship between Vitamin Deficiencies and Co-Occurring Symptoms in Autism Spectrum Disorder.

Authors:  Madalina-Andreea Robea; Alina-Costina Luca; Alin Ciobica
Journal:  Medicina (Kaunas)       Date:  2020-05-20       Impact factor: 2.430

7.  Autism spectrum disorders.

Authors:  Kara Fitzgerald; Mark Hyman; Kathie Swift
Journal:  Glob Adv Health Med       Date:  2012-09

8.  My experience learning about autism.

Authors:  Daniel A Rossignol
Journal:  Glob Adv Health Med       Date:  2013-11

9.  Correlation between Nutrition and Symptoms: Nutritional Survey of Children with Autism Spectrum Disorder in Chongqing, China.

Authors:  Xiao Liu; Juan Liu; Xueqin Xiong; Ting Yang; Nali Hou; Xiaohua Liang; Jie Chen; Qian Cheng; Tingyu Li
Journal:  Nutrients       Date:  2016-05-14       Impact factor: 5.717

10.  The Pivotal Role of Aldehyde Toxicity in Autism Spectrum Disorder: The Therapeutic Potential of Micronutrient Supplementation.

Authors:  Frances Jurnak
Journal:  Nutr Metab Insights       Date:  2016-06-14
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