Literature DB >> 10865148

Localization of linear B-cell epitopes on infectious bronchitis virus nucleocapsid protein.

J N Seah1, L Yu, J Kwang.   

Abstract

The nucleocapsid (N) protein of many viruses is highly conserved, immunogenic, and abundantly expressed during infection. These features make it a suitable candidate for diagnostic applications. The nucleocapsid protein of infectious bronchitis virus (IBV) was dissected into 12 fragments and expressed in Escherichia coli. Sera against Australia T, China Ch5, Singapore P4, USA M41 and China T3 isolates were used to study the conservation and localization of the antigenic region on the IBV nucleocapsid protein. Our results show linear immunodominant epitopes, which were found in three fragments covering amino acid residues 175-241, 310-370 and 360-409.

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Year:  2000        PMID： 10865148     DOI： 10.1016/s0378-1135(00)00202-9

Source DB:  PubMed          Journal:  Vet Microbiol        ISSN： 0378-1135            Impact factor:   3.293


  17 in total

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Authors:  Junji Xing; Shengwang Liu; Zongxi Han; Yuhao Shao; Huixin Li; Xiangang Kong
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4.  Development of a Western blot assay for detection of antibodies against coronavirus causing severe acute respiratory syndrome.

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Journal:  Clin Diagn Lab Immunol       Date:  2004-03

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6.  The epitope study on the SARS-CoV nucleocapsid protein.

Authors:  Shuting Li; Liang Lin; Hao Wang; Jianning Yin; Yan Ren; Zhe Zhao; Jie Wen; Cuiqi Zhou; Xumin Zhang; Xiaolei Li; Jingqiang Wang; Zhengfeng Zhou; Jinxiu Liu; Jianmin Shao; Tingting Lei; Jianqiu Fang; Ningzhi Xu; Siqi Liu
Journal:  Genomics Proteomics Bioinformatics       Date:  2003-08       Impact factor: 7.691

7.  Two novel neutralizing antigenic epitopes of the s1 subunit protein of a QX-like avian infectious bronchitis virus strain Sczy3 as revealed using a phage display peptide library.

Authors:  Nianli Zou; Jing Xia; Fuyan Wang; Zhenzhen Duan; Dan Miao; Qigui Yan; Sanjie Cao; Xintian Wen; Ping Liu; Yong Huang
Journal:  Vet Immunol Immunopathol       Date:  2015-08-19       Impact factor: 2.046

8.  Priming with a DNA vaccine and boosting with an inactivated vaccine enhance the immune response against infectious bronchitis virus.

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Journal:  J Virol Methods       Date:  2010-03-20       Impact factor: 2.014

9.  Relative rates of non-pneumonic SARS coronavirus infection and SARS coronavirus pneumonia.

Authors:  Patrick C Y Woo; Susanna K P Lau; Hoi-wah Tsoi; Kwok-hung Chan; Beatrice H L Wong; Xiao-yan Che; Victoria K P Tam; Sidney C F Tam; Vincent C C Cheng; Ivan F N Hung; Samson S Y Wong; Bo-jian Zheng; Yi Guan; Kwok-yung Yuen
Journal:  Lancet       Date:  2004-03-13       Impact factor: 79.321

10.  Enhancement of the immunogenicity of an infectious bronchitis virus DNA vaccine by a bicistronic plasmid encoding nucleocapsid protein and interleukin-2.

Authors:  Mengjun Tang; Hongning Wang; Sheng Zhou; Guobao Tian
Journal:  J Virol Methods       Date:  2008-03-07       Impact factor: 2.014
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