Accuracy of two dipolar inverse algorithms applying reciprocity for forward calculation.

Two inverse algorithms were applied for solving the EEG inverse problem assuming a single dipole as a source model. For increasing the efficiency of the forward computations the lead field approach based on the reciprocity theorem was applied. This method provides a procedure to calculate the computationally heavy forward problem by a single solution for each EEG lead. A realistically shaped volume conductor model with five major tissue compartments was employed to obtain the lead fields of the standard 10-20 EEG electrode system and the scalp potentials generated by simulated dipole sources. A least-squares method and a probability-based method were compared in their performance to reproduce the dipole source based on the reciprocal forward solution. The dipole localization errors were 0 to 9 mm and 2 to 22 mm without and with added noise in the simulated data, respectively. The two different inverse algorithms operated mainly very similarly. The lead field method appeared applicable for the solution of the inverse problem and especially useful when a number of sources, e.g., multiple EEG time instances, must be solved. Copyright 2000 Academic Press.