Biomaterials in functional reconstruction.

Recent initiatives in the development of biomaterials for functional reconstruction involve the alloplasts, the biological and the bioengineered biomaterials. Anti-infective alloplastic biomaterials (Foley catheters coated with rifampicin/minocycline bonded to silicone or ciprofloxacin liposome-containing hydrogel) allow a reduction in the rate of bacterial contamination, but the risk of future bacterial resistance is a matter for concern. New generations of biologic collagen-based tissue-matrix grafts are derived from bladder (bladder acellular matrix graft and bladder submucosa collagen matrix), ureter or small intestine (subintestinal submucosa). There are high hopes that these materials may have applications in augmentation cystoplasty. Using tissue engineering (autologous cells expanded in vitro and grafted onto biodegradable matrix), biocompatible malleable penile prostheses have been obtained experimentally. Most of the results obtained with these new biomaterials are exclusively experimental, but they offer great hope for future functional reconstruction of the urinary tract.