Literature DB >> 10858258

Adjuvant activity of a nontoxic mutant of Escherichia coli heat-labile enterotoxin on systemic and mucosal immune responses elicited against a heterologous antigen carried by a live Salmonella enterica serovar Typhimurium vaccine strain.

H C Guillobel1, J I Carinhanha, L Cárdenas, J D Clements, D F de Almeida, L C Ferreira.   

Abstract

Systemic and mucosal antibody responses against both the major subunit of colonization factor antigen I (CFA/I) of enterotoxigenic Escherichia coli (ETEC) and the somatic lipopolysaccharide expressed by recombinant bivalent Salmonella vaccine strains were significantly enhanced by coadministration of a detoxified derivative with preserved adjuvant effects of the ETEC heat-labile toxin, LT((R192G)). The results further support the adjuvant effects of LT((R192G)) and represent a simple alternative to improve responses against passenger antigens expressed by orally delivered Salmonella vaccine strains.

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Year:  2000        PMID： 10858258      PMCID： PMC101767          DOI： 10.1128/IAI.68.7.4349-4353.2000

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  30 in total

Review 1.  Cholera toxin and its subunits as potential oral adjuvants.

Authors:  C O Elson
Journal:  Curr Top Microbiol Immunol       Date:  1989       Impact factor: 4.291

2.  Molecular cloning and nucleotide sequence of the colonization factor antigen I gene of Escherichia coli.

Authors:  T K Karjalainen; D G Evans; M So; C H Lee
Journal:  Infect Immun       Date:  1989-04       Impact factor: 3.441

3.  Administration of purified colonization factor antigens (CFA/I, CFA/II) of enterotoxigenic Escherichia coli to volunteers. Response to challenge with virulent enterotoxigenic Escherichia coli.

Authors:  D G Evans; D Y Graham; D J Evans
Journal:  Gastroenterology       Date:  1984-10       Impact factor: 22.682

4.  Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines.

Authors:  S K Hoiseth; B A Stocker
Journal:  Nature       Date:  1981-05-21       Impact factor: 49.962

5.  Purification and characterization of the CFA/I antigen of enterotoxigenic Escherichia coli.

Authors:  D G Evans; D J Evans; S Clegg; J A Pauley
Journal:  Infect Immun       Date:  1979-08       Impact factor: 3.441

6.  Cloning and expression of colonization factor antigen I (CFA/I) epitopes of enterotoxigenic Escherichia coli (ETEC) in Salmonella flagellin.

Authors:  M G Luna; M M Martins; S M Newton; S O Costa; D F Almeida; L C Ferreira
Journal:  Res Microbiol       Date:  1997 Mar-Apr       Impact factor: 3.992

7.  Adjuvant activity of Escherichia coli heat-labile enterotoxin and effect on the induction of oral tolerance in mice to unrelated protein antigens.

Authors:  J D Clements; N M Hartzog; F L Lyon
Journal:  Vaccine       Date:  1988-06       Impact factor: 3.641

8.  In vivo expression and immunoadjuvancy of a mutant of heat-labile enterotoxin of Escherichia coli in vaccine and vector strains of Vibrio cholerae.

Authors:  E T Ryan; T I Crean; M John; J R Butterton; J D Clements; S B Calderwood
Journal:  Infect Immun       Date:  1999-04       Impact factor: 3.441

9.  Native and mutant forms of cholera toxin and heat-labile enterotoxin effectively enhance protective efficacy of live attenuated and heat-killed Shigella vaccines.

Authors:  A B Hartman; L L Van De Verg; M M Venkatesan
Journal:  Infect Immun       Date:  1999-11       Impact factor: 3.441

10.  Presence of colonization factor antigens on fresh isolates of fecal Escherichia coli: a prospective study.

Authors:  L Gothefors; C Ahrén; B Stoll; D K Barua; F Orskov; M A Salek; A M Svennerholm
Journal:  J Infect Dis       Date:  1985-12       Impact factor: 5.226
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  12 in total

1.  Glycosylated F4 (K88) fimbrial adhesin FaeG expressed in barley endosperm induces ETEC-neutralizing antibodies in mice.

Authors:  Jussi J Joensuu; Mirkka Kotiaho; Teemu H Teeri; Leena Valmu; Anna Maria Nuutila; Kirsi-Marja Oksman-Caldentey; Viola Niklander-Teeri
Journal:  Transgenic Res       Date:  2006-06       Impact factor: 2.788

2.  Protection against aerosolized Yersinia pestis challenge following homologous and heterologous prime-boost with recombinant plague antigens.

Authors:  Audrey Glynn; Chad J Roy; Bradford S Powell; Jeffrey J Adamovicz; Lucy C Freytag; John D Clements
Journal:  Infect Immun       Date:  2005-08       Impact factor: 3.441

3.  Concomitant enterotoxigenic Escherichia coli infection induces increased immune responses to Vibrio cholerae O1 antigens in patients with cholera in Bangladesh.

Authors:  Fahima Chowdhury; Yasmin A Begum; Mohammad Murshid Alam; Ashraful I Khan; Tanvir Ahmed; M Saruar Bhuiyan; Jason B Harris; Regina C LaRocque; Abu S G Faruque; Hubert Endtz; Edward T Ryan; Alejandro Cravioto; Ann-Mari Svennerholm; Stephen B Calderwood; Firdausi Qadri
Journal:  Infect Immun       Date:  2010-02-22       Impact factor: 3.441

4.  Construction and phase I clinical evaluation of the safety and immunogenicity of a candidate enterotoxigenic Escherichia coli vaccine strain expressing colonization factor antigen CFA/I.

Authors:  Arthur K Turner; Juliet C Beavis; Jonathan C Stephens; Judith Greenwood; Cornelia Gewert; Nicola Thomas; Alison Deary; Gabriella Casula; Alexandra Daley; Paul Kelly; Roger Randall; Michael J Darsley
Journal:  Infect Immun       Date:  2006-02       Impact factor: 3.441

5.  Combined vaccine regimen based on parenteral priming with a DNA vaccine and administration of an oral booster consisting of a recombinant Salmonella enterica serovar Typhimurium vaccine strain for immunization against infection with human-derived enterotoxigenic Escherichia coli strains.

Authors:  Marcio O Lásaro; Wilson B Luiz; Maria E Sbrogio-Almeida; Lucilia S Nishimura; Beatriz E C Guth; Luis C S Ferreira
Journal:  Infect Immun       Date:  2004-11       Impact factor: 3.441

6.  Oral spore vaccine based on live attenuated nontoxinogenic Bacillus anthracis expressing recombinant mutant protective antigen.

Authors:  R Aloni-Grinstein; O Gat; Z Altboum; B Velan; S Cohen; A Shafferman
Journal:  Infect Immun       Date:  2005-07       Impact factor: 3.441

7.  Host and bacterial factors affecting induction of immune responses to flagellin expressed by attenuated Salmonella vaccine strains.

Authors:  M E Sbrogio-Almeida; T Mosca; L M Massis; I A Abrahamsohn; L C S Ferreira
Journal:  Infect Immun       Date:  2004-05       Impact factor: 3.441

8.  Distinctive immunomodulatory and inflammatory properties of the Escherichia coli type II heat-labile enterotoxin LT-IIa and its B pentamer following intradermal administration.

Authors:  Camila Mathias-Santos; Juliana F Rodrigues; Maria Elisabete Sbrogio-Almeida; Terry D Connell; Luís C S Ferreira
Journal:  Clin Vaccine Immunol       Date:  2011-06-15

9.  Human papillomavirus virus-like particles are efficient oral immunogens when coadministered with Escherichia coli heat-labile enterotoxin mutant R192G or CpG DNA.

Authors:  S Gerber; C Lane; D M Brown; E Lord; M DiLorenzo; J D Clements; E Rybicki; A L Williamson; R C Rose
Journal:  J Virol       Date:  2001-05       Impact factor: 5.103

10.  Facilitated intranasal induction of mucosal and systemic immunity to mutans streptococcal glucosyltransferase peptide vaccines.

Authors:  D J Smith; W F King; L A Barnes; D Trantolo; D L Wise; M A Taubman
Journal:  Infect Immun       Date:  2001-08       Impact factor: 3.441
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