| Literature DB >> 10856521 |
T Suehiro1, T Nakamura, M Inoue, T Shiinoki, Y Ikeda, Y Kumon, M Shindo, H Tanaka, K Hashimoto.
Abstract
Human serum paraoxonase (PON1) is an esterase that has been shown to decrease the susceptibility of lipoproteins to lipid peroxidation. We found a polymorphism of cytosine/thymidine (-108C/T, the number is from the ATG codon) in the upstream region of the PON1 gene. The luciferase activity was lower in the -108T allele than in the -108C allele. The serum PON1 concentrations in 132 normal subjects were as follows: -108CC>-108CT and>-108TT genotypes. The polymorphism upstream from the PON1 gene is associated with transcription of the PON1 gene and the serum PON1 concentration.Entities:
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Year: 2000 PMID： 10856521 DOI： 10.1016/s0021-9150(99)00379-2
Source DB: PubMed Journal: Atherosclerosis ISSN： 0021-9150 Impact factor: 5.162