Differences in in vitro fertilization (IVF) outcome between white and black women in an inner-city, university-based IVF program.

OBJECTIVE: To compare IVF outcomes between white and black women in an inner-city, university-based IVF program.
DESIGN: Retrospective study.
SETTING: University-based IVF program. PATIENT(S): Ninety-five white women undergoing 121 cycles and 37 black women undergoing 47 cycles. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Implantation rate and pregnancy rate (PR). RESULT(S): Black women constituted 28. 0% of the population and underwent 28.0% of the total cycles. There were no statistically significant differences in age, basal FSH, number of ampules, duration of stimulation, endometrial thickness, P on the day of hCG, cancellation rate, number of oocytes, or embryos transferred. However, the duration of infertility, body mass index (BMI), incidence of tubal-factor infertility, and peak E(2) levels were significantly higher in black women. In addition, a larger proportion of black women required aggressive stimulation than white women (70.2% and 43.0%). Both implantation rates and clinical PRs were significantly lower in black women than in white women (9.8% and 19.2% compared with 23.4% and 42.2%, respectively). CONCLUSION(S): Black women have poorer IVF outcomes than white women. These differences can be partly explained by higher BMI, longer duration of infertility, higher incidence of tubal-factor infertility, and higher peak E(2).