| Literature DB >> 10853673 |
P M Brophy1, A M Campbell, A J van Eldik, P H Teesdale-Spittle, E Liebau, M F Wang.
Abstract
A series of beta-carbonyl substituted glutathione conjugates were prepared and evaluated as inhibitors of OvGST2. Their specificity for the parasite derived protein was assessed through comparison with their inhibition of human piGST. Inhibition of OvGST2 has been demonstrated at low micromolar concentrations for these conjugates and selectivity for OvGST2 over human pi-GST of greater than 10-fold has been achieved.Entities:
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Year: 2000 PMID： 10853673 DOI： 10.1016/s0960-894x(00)00142-6
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823