| Literature DB >> 10853650 |
T Hanano1, K Adachi, Y Aoki, H Morimoto, Y Naka, M Hisadome, T Fukuda, H Sumichika.
Abstract
Phenylpiperazine derivatives were synthesized as dual cytokine regulators with TNF-alpha suppressing and IL-10 augmenting activity. Lead optimization led to compound 5k having the potent regulatory activity and demonstrating remarkable protective effects against the lethal challenge of LPS in mice. suggesting that 5k would be a promising drug candidate for the treatment of TNF-alpha associated diseases including septic shock.Entities:
Mesh：
Substances：
Year: 2000 PMID： 10853650 DOI： 10.1016/s0960-894x(00)00128-1
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823