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Literature DB >> 10852137

Etiology of autoimmunity.

Abstract

Autoimmunity reflects the destruction of host tissue by the immune system. In my laboratory we are focused on understanding autoimmunity and the complex regulation of the autoimmune process. We believe that host defense mechanisms, which are normally activated to fight microorganisms, can malfunction and attack self. The role of cytokines and other host-elicited factors are a major focus of our group.

Entities: Disease

Mesh：

Year: 2000 PMID： 10852137 DOI： 10.1385/IR:21:2-3:357

Source DB: PubMed Journal: Immunol Res ISSN： 0257-277X Impact factor: 2.829

14 in total

1. Immunotherapy of the nonobese diabetic mouse: treatment with an antibody to T-helper lymphocytes.

Authors: J A Shizuru; C Taylor-Edwards; B A Banks; A K Gregory; C G Fathman
Journal: Science Date: 1988-04-29 Impact factor: 47.728

2. Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes.

Authors: M A Atkinson; M A Bowman; L Campbell; B L Darrow; D L Kaufman; N K Maclaren
Journal: J Clin Invest Date: 1994-11 Impact factor: 14.808

3. The natural history of lymphocyte subsets infiltrating the pancreas of NOD mice.

Authors: A Signore; P Pozzilli; E A Gale; D Andreani; P C Beverley
Journal: Diabetologia Date: 1989-05 Impact factor: 10.122

4. Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes.

Authors: D L Kaufman; M Clare-Salzler; J Tian; T Forsthuber; G S Ting; P Robinson; M A Atkinson; E E Sercarz; A J Tobin; P V Lehmann
Journal: Nature Date: 1993-11-04 Impact factor: 49.962

5. Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus.

Authors: D L Kaufman; M G Erlander; M Clare-Salzler; M A Atkinson; N K Maclaren; A J Tobin
Journal: J Clin Invest Date: 1992-01 Impact factor: 14.808

6. IL-10 impacts autoimmune diabetes via a CD8+ T cell pathway circumventing the requirement for CD4+ T and B lymphocytes.

Authors: B Balasa; J D Davies; J Lee; A Good; B T Yeung; N Sarvetnick
Journal: J Immunol Date: 1998-10-15 Impact factor: 5.422

10. Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles.

Authors: M Croft; L Carter; S L Swain; R W Dutton
Journal: J Exp Med Date: 1994-11-01 Impact factor: 14.307

3 in total

Etiology of autoimmunity.

1. Immunotherapy of the nonobese diabetic mouse: treatment with an antibody to T-helper lymphocytes.

2. Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes.

3. The natural history of lymphocyte subsets infiltrating the pancreas of NOD mice.

4. Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes.

5. Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus.

6. IL-10 impacts autoimmune diabetes via a CD8+ T cell pathway circumventing the requirement for CD4+ T and B lymphocytes.

7. T helper cell subsets in insulin-dependent diabetes.

8. Diabetes induced by Coxsackie virus: initiation by bystander damage and not molecular mimicry.

9. IL-10 is necessary and sufficient for autoimmune diabetes in conjunction with NOD MHC homozygosity.

10. Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles.

Review 1. Genetic vaccination for re-establishing T-cell tolerance in type 1 diabetes.

2. Parameters influencing antigen-specific immunotherapy for Type 1 diabetes.

3. Parameters influencing antigen-specific immunotherapy for type 1 diabetes.