| Literature DB >> 18543112 |
Abstract
Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease in which the insulin producing beta cells are destroyed. Antigen-based immunotherapy provides an approach to selectively tolerize pathogenic beta cell-specific T cells, while leaving the remainder of the immune system intact. In this chapter, we discuss our group's experience in defining the parameters that impact the efficacy of beta cell antigen "vaccination" for the prevention and treatment of T1D.Entities:
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Year: 2008 PMID: 18543112 DOI: 10.1007/s12026-008-8020-6
Source DB: PubMed Journal: Immunol Res ISSN: 0257-277X Impact factor: 2.829