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Literature DB >> 10852111

Regulation of cell function by Rho family GTPases.

Abstract

Rho GTPases act as molecular switches to control many basic cellular activities that are also critical to the specialized functions of phagocytic leukocytes. Our laboratory has studied the regulation of Rho GTPase function, how these GTPases interact with specific effectors to modulate cell function, and how these events are coordinated in the stimulated cell. Areas of major interest include NADPH oxidase regulation by Rac2, Rac- and Cdc42-mediated control of the actin-myosin cytoskeleton via p21-activated kinase (PAK), and modulation of the apoptotic program by Rho GTPases and PAK.

Entities: Gene

Mesh：

Substances：
rho GTP-Binding Proteins

Year: 2000 PMID： 10852111 DOI： 10.1385/IR:21:2-3:139

Source DB: PubMed Journal: Immunol Res ISSN： 0257-277X Impact factor: 2.829

40 in total

Review 1. Interplay between Ras-related and heterotrimeric GTP binding proteins: lifestyles of the BIG and little.

Authors: G M Bokoch
Journal: FASEB J Date: 1996-09 Impact factor: 5.191

2. Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes.

Authors: E Manser; H Y Huang; T H Loo; X Q Chen; J M Dong; T Leung; L Lim
Journal: Mol Cell Biol Date: 1997-03 Impact factor: 4.272

3. D4-GDI, a substrate of CPP32, is proteolyzed during Fas-induced apoptosis.

Authors: S Na; T H Chuang; A Cunningham; T G Turi; J H Hanke; G M Bokoch; D E Danley
Journal: J Biol Chem Date: 1996-05-10 Impact factor: 5.157

4. Translocation of Rac correlates with NADPH oxidase activation. Evidence for equimolar translocation of oxidase components.

Authors: M T Quinn; T Evans; L R Loetterle; A J Jesaitis; G M Bokoch
Journal: J Biol Chem Date: 1993-10-05 Impact factor: 5.157

Review 5. Chemoattractant signaling and leukocyte activation.

Authors: G M Bokoch
Journal: Blood Date: 1995-09-01 Impact factor: 22.113

Review 6. Emerging concepts in the Ras superfamily of GTP-binding proteins.

Authors: G M Bokoch; C J Der
Journal: FASEB J Date: 1993-06 Impact factor: 5.191

7. PAK3 mutation in nonsyndromic X-linked mental retardation.

Authors: K M Allen; J G Gleeson; S Bagrodia; M W Partington; J C MacMillan; R A Cerione; J C Mulley; C A Walsh
Journal: Nat Genet Date: 1998-09 Impact factor: 38.330

8. Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1.

Authors: S Zhang; J Han; M A Sells; J Chernoff; U G Knaus; R J Ulevitch; G M Bokoch
Journal: J Biol Chem Date: 1995-10-13 Impact factor: 5.157

9. PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia.

Authors: A Abo; J Qu; M S Cammarano; C Dan; A Fritsch; V Baud; B Belisle; A Minden
Journal: EMBO J Date: 1998-11-16 Impact factor: 11.598

10. Interaction of the Nck adapter protein with p21-activated kinase (PAK1).

Authors: G M Bokoch; Y Wang; B P Bohl; M A Sells; L A Quilliam; U G Knaus
Journal: J Biol Chem Date: 1996-10-18 Impact factor: 5.157

20 in total

1. Approaches to studying cellular signaling: a primer for morphologists.

Authors: Kathy Kay Hartford Svoboda; Wende R Reenstra
Journal: Anat Rec Date: 2002-04-15

2. Dictyostelium PAKc is required for proper chemotaxis.

Authors: Susan Lee; Francisco Rivero; Kyung Chan Park; Emerald Huang; Satoru Funamoto; Richard A Firtel
Journal: Mol Biol Cell Date: 2004-10-13 Impact factor: 4.138

3. Neutrophil polarization: spatiotemporal dynamics of RhoA activity support a self-organizing mechanism.

Authors: Kit Wong; Olivier Pertz; Klaus Hahn; Henry Bourne
Journal: Proc Natl Acad Sci U S A Date: 2006-02-28 Impact factor: 11.205

Review 4. Small Rho GTPases in the control of cell shape and mobility.

Authors: Arun Murali; Krishnaraj Rajalingam
Journal: Cell Mol Life Sci Date: 2013-11-26 Impact factor: 9.261

5. The role of Rac2 in regulating neutrophil production in the bone marrow and circulating neutrophil counts.

Authors: John C Gomez; Jindrich Soltys; Keiichi Okano; Mary C Dinauer; Claire M Doerschuk
Journal: Am J Pathol Date: 2008-06-26 Impact factor: 4.307

Review 6. P21-activated kinase in inflammatory and cardiovascular disease.

Authors: Domenico M Taglieri; Masuko Ushio-Fukai; Michelle M Monasky
Journal: Cell Signal Date: 2014-05-02 Impact factor: 4.315

7. Morphine decreases bacterial phagocytosis by inhibiting actin polymerization through cAMP-, Rac-1-, and p38 MAPK-dependent mechanisms.

Authors: Jana Ninković; Sabita Roy
Journal: Am J Pathol Date: 2012-01-14 Impact factor: 4.307