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Literature DB >> 1084697

Genetic control of the immune response to poly(Glu52Lys33Tyr15) in neonatally thymectomized high and low responder rats.

Abstract

The immune response to poly (Glu52Lys33Tyr15) is under polygenic control and linked to the major histocompatibility complex of the rat. Aggregation of this antigen with methylated bovine serum albumin (MeBSA) eliminates the expression of genetic control by increasing the response of low responders and decreasing that of high responders. Humoral and cellular aspects of the immune response to both unaggregated and aggregated poly (Glu52Lys33Tyr15) were investigated in neonatally thymectomized high-responder ACI and low-responder F344 rats. T cells are necessary for responses to unaggregated poly (Glu52Lys33Tyr15) since thymectomy significantly decreased numbers of antibody-forming cells and serum antibody levels, and delayed hypersensitivity responses and antigen-induced in vitro proliferation. However, thymectomy had no significant effect on these parameters of immune responsiveness in either ACI or F344 rats immunized with poly (Glu52Lys33Tyr15)/MeBSA. Aggregation also increased IgG production and delayed hypersensitivity and antibody affinity in low responders.

Entities: Chemical Disease Gene Species

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Year: 1976 PMID： 1084697 PMCID： PMC2032349

Source DB: PubMed Journal: Am J Pathol ISSN： 0002-9440 Impact factor: 4.307

33 in total

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Authors: N SUEOKA; T Y CHENG
Journal: J Mol Biol Date: 1962-03 Impact factor: 5.469

2. Characterization of an immune response gene in rats.

Authors: U Würzburg; H Schütt-Gerowitt; K Rajewsky
Journal: Eur J Immunol Date: 1973-12 Impact factor: 5.532

3. Role of T lymphocytes in the humoral immune response. I. Proliferation of B lymphocytes in thymus-deprived mice.

Authors: J M Davie; W E Paul
Journal: J Immunol Date: 1974-11 Impact factor: 5.422

4. Streptococcal group A carbohydrate antibodies in mice: evidence for strain differences in magnitude and restriction of the response, and for thymus dependence.

Authors: D G Braun; B Kindred; E B Jacobson
Journal: Eur J Immunol Date: 1972-04 Impact factor: 5.532

Review 5. The regulatory influence of activated T cells on B cell responses to antigen.

Authors: D H Katz; B Benacerraf
Journal: Adv Immunol Date: 1972 Impact factor: 3.543

6. Immunological B memory in thymus deprived mice.

Authors: G E Roelants; B A Askonas
Journal: Nat New Biol Date: 1972-09-13

7. Activation of T and B lymphocytes by insoluble phytomitogens.

Authors: M F Greaves; S Bauminger
Journal: Nat New Biol Date: 1972-01-19

8. Role of the thymus in immune reactions in rats. II. Suppressive effect of thymectomy at birth on reactions of delayed (cellular) hypersensitivity and the circulating small lymphocyte.

Authors: B G ARNASON; B D JANKOVIC; B H WAKSMAN; C WENNERSTEN
Journal: J Exp Med Date: 1962-08-01 Impact factor: 14.307

9. Occurrence of a theta-like antigen in rats.

Authors: T C Douglas
Journal: J Exp Med Date: 1972-11-01 Impact factor: 14.307

10. Role of the thymus in immune ractions in rats. I. The immunologic response to bovine serum albumin (antibody formation, Arthus reactivity, and delayed hypersensitivity) in rats thymectomized or splenectomized at various times after birth.

Authors: B D JANKOVIC; B H WAKSMAN; B G ARNASON
Journal: J Exp Med Date: 1962-08-01 Impact factor: 14.307

4 in total