Literature DB >> 10843580

Novel cytotoxic diterpenes from Casearia arborea.

J A Beutler1, K L McCall, K Herbert, D L Herald, G R Pettit, T Johnson, R H Shoemaker, M R Boyd.   

Abstract

Cytotoxicity-guided fractionation of the dichloromethane-methanol extract of the roots of Casearia arborea yielded five novel clerodane diterpenes, casearborins A-E (1-5), as well as cucurbitacin B. The presence of cucurbitacins glycosides was also detected. The absolute configuration of casearborin E was determined by X-ray crystallography.

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Year:  2000        PMID： 10843580     DOI： 10.1021/np990553r

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  3 in total

Review 1.  Clerodane diterpenes: sources, structures, and biological activities.

Authors:  Rongtao Li; Susan L Morris-Natschke; Kuo-Hsiung Lee
Journal:  Nat Prod Rep       Date:  2016-07-18       Impact factor: 13.423

2.  Cytotoxic clerodane diterpenoids and their hydrolysis products from Casearia nigrescens from the rainforest of Madagascar.

Authors:  Russell B Williams; Andrew Norris; James S Miller; Chris Birkinshaw; Fidy Ratovoson; Rabodo Andriantsiferana; Vincent E Rasamison; David G I Kingston
Journal:  J Nat Prod       Date:  2007-02       Impact factor: 4.050

3.  Clerodane diterpenes from Casearia arguta that act as synergistic TRAIL sensitizers.

Authors:  Emily L Whitson; Cheryl L Thomas; Curtis J Henrich; Thomas J Sayers; James B McMahon; Tawnya C McKee
Journal:  J Nat Prod       Date:  2010-11-10       Impact factor: 4.050
  3 in total

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