Literature DB >> 10843222

Novel alpha-glucosidase inhibitors with a tetrachlorophthalimide skeleton.

S Sou1, S Mayumi, H Takahashi, R Yamasaki, S Kadoya, M Sodeoka, Y Hashimoto.   

Abstract

Novel alpha-glucosidase inhibitors with a tetrachlorophthalimide skeleton were prepared and their structure-activity relationships were analyzed. Among them, N-phenyl-4,5,6,7-tetrachlorophthalimide (CPOP: 2) and N-(4-phenylbutyl)-4,5,6,7-tetrachlorophthalimide (CP4P: 6) showed very potent inhibitory activity, being more potent than 1-deoxynojirimycin (dNM: 1). Mechanistic studies revealed that CPOP (2) and CP4P (6) inhibit alpha-glucosidase non-competitively and competitively, respectively.

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Year:  2000        PMID： 10843222     DOI： 10.1016/s0960-894x(00)00161-x

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

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  6 in total

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