| Literature DB >> 10841896 |
M Murakami1, O Nakagawasai, S Fujii, M Hosono, S Hozumi, A Esashi, R Taniguchi, T Okamura, T Suzuki, H Sasano, T Yanagisawa, K Tan-no, T Tadano, K Kitamura, K Kisara.
Abstract
We investigated the antinociceptic effects of cilnidipine, a dihydropyridine derivative which acts on both L- and N-type voltage-dependent calcium channels, in mice. Intrathecally injected cilnidipine showed significant analgesic effect in formalin test. Cilnidipine significantly suppressed N-type currents in dorsal root ganglion (DRG) cells. Our findings apparently support the idea that cilnidipine attenuates synaptic neurotransmission by inhibiting N-type calcium channels in DRG neurons.Entities:
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Year: 2000 PMID： 10841896 DOI： 10.1016/s0006-8993(00)02295-2
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252