Literature DB >> 10838437

High Throughput Screening for Drug Discovery: Continually Transitioning into New Technology.

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Abstract

Those working in HTS laboratories, pressured to find increasing numbers of drug leads while containing costs, are seeking larger compound sets, more automated systems to screen them faster, and an integrated set of equipment and consumables. Enabling technologies are continually being developed and suppliers are teaming up to supply integrated equipment and consumable sets. Miniaturization, microfluidic chips, subnanoliter dispensing, fluorescence, homogeneous assays for HTS, and virtual screening are just some of the evolving tools that HTS experts are continually evaluating and incorporating into drug discovery operations.

Entities:  

Year:  1999        PMID: 10838437     DOI: 10.1177/108705719900400405

Source DB:  PubMed          Journal:  J Biomol Screen        ISSN: 1087-0571


  9 in total

1.  Current trends in lead discovery: are we looking for the appropriate properties?

Authors:  Tudor I Oprea
Journal:  J Comput Aided Mol Des       Date:  2002 May-Jun       Impact factor: 3.686

Review 2.  Current trends in lead discovery: are we looking for the appropriate properties?

Authors:  Tudor I Oprea
Journal:  Mol Divers       Date:  2002       Impact factor: 2.943

Review 3.  The influence of lead discovery strategies on the properties of drug candidates.

Authors:  György M Keserü; Gergely M Makara
Journal:  Nat Rev Drug Discov       Date:  2009-03       Impact factor: 84.694

4.  Re-engineering natural products to engage new biological targets.

Authors:  Stephen E Motika; Paul J Hergenrother
Journal:  Nat Prod Rep       Date:  2020-11-18       Impact factor: 13.423

5.  RepurposeVS: A Drug Repurposing-Focused Computational Method for Accurate Drug-Target Signature Predictions.

Authors:  Naiem T Issa; Oakland J Peters; Stephen W Byers; Sivanesan Dakshanamurthy
Journal:  Comb Chem High Throughput Screen       Date:  2015       Impact factor: 1.339

6.  Decoration of dihydropyrimidine and dihydropyridine scaffolds with sugars via Biginelli and Hantzsch multicomponent reactions: an efficient entry to a collection of artificial nucleosides.

Authors:  Alessandro Dondoni; Alessandro Massi
Journal:  Mol Divers       Date:  2003       Impact factor: 2.943

7.  High-Throughput Screen Identifying the Thiosemicarbazone NSC319726 Compound as a Potent Antimicrobial Lead Against Resistant Strains of Escherichia coli.

Authors:  Carmen Sadaka; Peter Damborg; Jeffrey L Watts
Journal:  Biomolecules       Date:  2018-12-07

8.  High-throughput cultivation and screening platform for unicellular phototrophs.

Authors:  Ulrich M Tillich; Nick Wolter; Katja Schulze; Dan Kramer; Oliver Brödel; Marcus Frohme
Journal:  BMC Microbiol       Date:  2014-09-16       Impact factor: 3.605

9.  Development of a miniaturized 3D organoid culture platform for ultra-high-throughput screening.

Authors:  Yuhong Du; Xingnan Li; Qiankun Niu; Xiulei Mo; Min Qui; Tingxuan Ma; Calvin J Kuo; Haian Fu
Journal:  J Mol Cell Biol       Date:  2020-08-01       Impact factor: 6.216

  9 in total

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