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Literature DB >> 10837626

Temperature-responsive gels and thermogelling polymer matrices for protein and peptide delivery.

Abstract

The explosive development of protein and peptide drugs has ushered in a great need for effective delivery systems for such drugs. Two decades of studies of protein delivery from polymeric systems has revealed the great potential of gels that respond to environmental stimuli, such as temperature, pH, etc. Protein and peptide release can be engineered to occur in a pulsatile mode. The mechanism of this release is greatly affected by polymer design. 'Intelligent' amphiphilic copolymers emerge as a novel trend in the application of thermodynamically stable self-assembling lyophilic colloids to protein and peptide delivery.

Entities: Chemical

Year: 1998 PMID： 10837626 DOI： 10.1016/s0169-409x(97)00121-x

Source DB: PubMed Journal: Adv Drug Deliv Rev ISSN： 0169-409X Impact factor: 15.470

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Cited

70 in total

1. Study of the breakup under shear of a new thermally reversible water-in-oil-in-water (W/O/W) multiple emulsion.

Authors: L Olivieri; M Seiller; L Bromberg; E Ron; P Couvreur; J L Grossiord
Journal: Pharm Res Date: 2001-05 Impact factor: 4.200

2. Formulation and characterization of poloxamine-based hydrogels as tissue sealants.

Authors: Eunhee Cho; Jeoung Soo Lee; Ken Webb
Journal: Acta Biomater Date: 2012-03-08 Impact factor: 8.947

3. A novel injectable chlorhexidine thermosensitive hydrogel for periodontal application: preparation, antibacterial activity and toxicity evaluation.

Authors: Qiu Xia Ji; Qing Sheng Zhao; Jing Deng; Rui Lü
Journal: J Mater Sci Mater Med Date: 2010-05-26 Impact factor: 3.896

4. Release of anti-inflammatory peptides from thermosensitive nanoparticles with degradable cross-links suppresses pro-inflammatory cytokine production.

Authors: Scott Poh; Jenny B Lin; Alyssa Panitch
Journal: Biomacromolecules Date: 2015-03-11 Impact factor: 6.988

Temperature-responsive gels and thermogelling polymer matrices for protein and peptide delivery.

1. Study of the breakup under shear of a new thermally reversible water-in-oil-in-water (W/O/W) multiple emulsion.

2. Formulation and characterization of poloxamine-based hydrogels as tissue sealants.

3. A novel injectable chlorhexidine thermosensitive hydrogel for periodontal application: preparation, antibacterial activity and toxicity evaluation.

4. Release of anti-inflammatory peptides from thermosensitive nanoparticles with degradable cross-links suppresses pro-inflammatory cytokine production.

5. Thermoreversible-mucoadhesive gel for nasal delivery of sumatriptan.

6. Smart Polymeric Gels: Redefining the Limits of Biomedical Devices.

7. Engineering of bio-hybrid materials by electrospinning polymer-microbe fibers.

8. Switchable Release of Entrapped Nanoparticles from Alginate Hydrogels.

9. Pulsatile release of parathyroid hormone from an implantable delivery system.

10. Sequential release of nanoparticle payloads from ultrasonically burstable capsules.