Literature DB >> 10836041

Gram-scale synthesis of (+)-discodermolide.

A B Smith1, M D Kaufman, T J Beauchamp, M J LaMarche, H Arimoto.   

Abstract

[formula: see text] A triply convergent, highly efficient second-generation synthesis of the potent antimitotic agent (+)-discodermolide (1) has been achieved on a 1-g scale.

Entities:  

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Year:  1999        PMID： 10836041     DOI： 10.1021/ol9910870

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  19 in total

1.  Structural Refinement of the Tubulin Ligand (+)-Discodermolide to Attenuate Chemotherapy-Mediated Senescence.

Authors:  Boying Guo; Alicia Rodriguez-Gabin; Andrea E Prota; Tobias Mühlethaler; Nan Zhang; Kenny Ye; Michel O Steinmetz; Susan Band Horwitz; Amos B Smith; Hayley M McDaid
Journal:  Mol Pharmacol       Date:  2020-06-26       Impact factor: 4.436

2.  (+)-Discodermolide: Total Synthesis, Construction of Novel Analogues, and Biological Evaluation.

Authors:  Amos B Smith; B Scott Freeze
Journal:  Tetrahedron       Date:  2007-01-07       Impact factor: 2.457

Review 3.  Lessons from the past and charting the future of marine natural products drug discovery and chemical biology.

Authors:  William H Gerwick; Bradley S Moore
Journal:  Chem Biol       Date:  2012-01-27

4.  Potentiation of taxol efficacy and by discodermolide in ovarian carcinoma xenograft-bearing mice.

Authors:  Gloria S Huang; Lluis Lopez-Barcons; B Scott Freeze; Amos B Smith; Gary L Goldberg; Susan Band Horwitz; Hayley M McDaid
Journal:  Clin Cancer Res       Date:  2006-01-01       Impact factor: 12.531

Review 5.  The Lithistida: important sources of compounds useful in biomedical research.

Authors:  Amy E Wright
Journal:  Curr Opin Biotechnol       Date:  2010-12       Impact factor: 9.740

Review 6.  Drug development from marine natural products.

Authors:  Tadeusz F Molinski; Doralyn S Dalisay; Sarah L Lievens; Jonel P Saludes
Journal:  Nat Rev Drug Discov       Date:  2008-12-19       Impact factor: 84.694

Review 7.  Advances in exploring the therapeutic potential of marine natural products.

Authors:  Xiao Liang; Danmeng Luo; Hendrik Luesch
Journal:  Pharmacol Res       Date:  2019-07-25       Impact factor: 7.658

8.  The first total synthesis and the second- or third-generation approach.

Authors:  Keiichi Ajito
Journal:  J Antibiot (Tokyo)       Date:  2016-04       Impact factor: 2.649

9.  Organic synthesis in the Smith Group: a personal selection of a dozen lessons learned at the University of Pennsylvania.

Authors:  Kevin P C Minbiole
Journal:  J Antibiot (Tokyo)       Date:  2016-03-02       Impact factor: 2.649

Review 10.  Microtubule stabilizing agents as potential treatment for Alzheimer's disease and related neurodegenerative tauopathies.

Authors:  Carlo Ballatore; Kurt R Brunden; Donna M Huryn; John Q Trojanowski; Virginia M-Y Lee; Amos B Smith
Journal:  J Med Chem       Date:  2012-09-28       Impact factor: 7.446
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