PURPOSE: To clarify the natural history and frequency of thyroid echo abnormalities in a random adult population by performing a 5-year follow-up study of subjects of a previous thyroid ultrasonographic (US) screening study. MATERIALS AND METHODS: In the original survey, 253 randomly selected adults were screened by means of thyroid US. US abnormalities were detected in 69 subjects (27%). In the follow-up study, 57 (83%) of those 69 subjects who had abnormalities were reexamined by means of thyroid US, fine-needle aspiration biopsy (FNAB), blood tests, and clinical examination. RESULTS: Of 34 individual nodules, 12 (35%) had grown. Biopsy was performed in 10 of them. Nine were benign. One was equivocal, was excised, and proved to be an adenomatous nodule. Eight nodules (24%) had diminished or disappeared. Seven new focal lesions were found in seven subjects (12%). Biopsy was performed in five of these lesions, and they were benign. At 5-year follow-up, no thyroid malignancies were detected among subjects with echo abnormalities at the primary US screening. CONCLUSION: Thyroid US abnormalities occurring in a random adult population are predominantly benign and clinically unimportant.
PURPOSE: To clarify the natural history and frequency of thyroid echo abnormalities in a random adult population by performing a 5-year follow-up study of subjects of a previous thyroid ultrasonographic (US) screening study. MATERIALS AND METHODS: In the original survey, 253 randomly selected adults were screened by means of thyroid US. US abnormalities were detected in 69 subjects (27%). In the follow-up study, 57 (83%) of those 69 subjects who had abnormalities were reexamined by means of thyroid US, fine-needle aspiration biopsy (FNAB), blood tests, and clinical examination. RESULTS: Of 34 individual nodules, 12 (35%) had grown. Biopsy was performed in 10 of them. Nine were benign. One was equivocal, was excised, and proved to be an adenomatous nodule. Eight nodules (24%) had diminished or disappeared. Seven new focal lesions were found in seven subjects (12%). Biopsy was performed in five of these lesions, and they were benign. At 5-year follow-up, no thyroid malignancies were detected among subjects with echo abnormalities at the primary US screening. CONCLUSION: Thyroid US abnormalities occurring in a random adult population are predominantly benign and clinically unimportant.
Authors: Anna Pisani Mainini; Cristian Monaco; Lorenzo Carlo Pescatori; Chiara De Angelis; Francesco Sardanelli; Luca Maria Sconfienza; Giovanni Mauri Journal: J Ultrasound Date: 2016-10-21
Authors: M Cappa; P Cambiaso; E Genovese; D Kiepe; M Colajacomo; S Giannico; G Giannone; R Guglielmi; L Papini; V Cannatà Journal: J Endocrinol Invest Date: 2011-12-21 Impact factor: 4.256
Authors: Jenny K Hoang; Barton F Branstetter; Andreia R Gafton; Wai K Lee; Christine M Glastonbury Journal: Cancer Imaging Date: 2013-03-26 Impact factor: 3.909
Authors: Won-Jin Moon; Jung Hwan Baek; So Lyung Jung; Dong Wook Kim; Eun Kyung Kim; Ji Young Kim; Jin Young Kwak; Jeong Hyun Lee; Joon Hyung Lee; Young Hen Lee; Dong Gyu Na; Jeong Seon Park; Sun Won Park Journal: Korean J Radiol Date: 2011-01-03 Impact factor: 3.500