Literature DB >> 10831454

Microbiological transformation of enrofloxacin by the fungus Mucor ramannianus.

I A Parshikov1, J P Freeman, J O Lay, R D Beger, A J Williams, J B Sutherland.   

Abstract

Enrofloxacin metabolism by Mucor ramannianus was investigated as a model for the biotransformation of veterinary fluoroquinolones. Cultures grown in sucrose-peptone broth were dosed with enrofloxacin. After 21 days, 22% of the enrofloxacin remained. Three metabolites were identified: enrofloxacin N-oxide (62% of the total absorbance), N-acetylciprofloxacin (8.0%), and desethylene-enrofloxacin (3.5%).

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Year:  2000        PMID： 10831454      PMCID： PMC110597          DOI： 10.1128/AEM.66.6.2664-2667.2000

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  19 in total

1.  Degradation of the fluoroquinolone enrofloxacin by wood-rotting fungi.

Authors:  R Martens; H G Wetzstein; F Zadrazil; M Capelari; P Hoffmann; N Schmeer
Journal:  Appl Environ Microbiol       Date:  1996-11       Impact factor: 4.792

2.  Isolation and identification of metabolites of ofloxacin in rats, dogs and monkeys.

Authors:  K Sudo; O Okazaki; M Tsumura; H Tachizawa
Journal:  Xenobiotica       Date:  1986-08       Impact factor: 1.908

3.  Antibacterial activity of the metabolites of ciprofloxacin and its significance in the bioassay.

Authors:  H J Zeiler; U Petersen; W Gau; H J Ploschke
Journal:  Arzneimittelforschung       Date:  1987-02

4.  Determination of a new antibacterial agent (AT-2266) and its metabolites in plasma and urine by high-performance liquid chromatography.

Authors:  R Nakamura; T Yamaguchi; Y Sekine; M Hashimoto
Journal:  J Chromatogr       Date:  1983-12-09

5.  Microbial models of soil metabolism: biotransformations of danofloxacin.

Authors:  Y Chen; J P Rosazza; C P Reese; H Y Chang; M A Nowakowski; J P Kiplinger
Journal:  J Ind Microbiol Biotechnol       Date:  1997 Nov-Dec       Impact factor: 3.346

6.  Degradation of ciprofloxacin by basidiomycetes and identification of metabolites generated by the brown rot fungus Gloeophyllum striatum.

Authors:  H G Wetzstein; M Stadler; H V Tichy; A Dalhoff; W Karl
Journal:  Appl Environ Microbiol       Date:  1999-04       Impact factor: 4.792

7.  Degradation of the fluoroquinolone enrofloxacin by the brown rot fungus Gloeophyllum striatum: identification of metabolites.

Authors:  H G Wetzstein; N Schmeer; W Karl
Journal:  Appl Environ Microbiol       Date:  1997-11       Impact factor: 4.792

8.  Effect of enrofloxacin administration on excretion of Salmonella ententidis by experimentally infected chickens and on quinolone resistance of their Escherichia coli flora.

Authors:  P A Barrow; M A Lovell; G Szmolleny; C K Murphy
Journal:  Avian Pathol       Date:  1998       Impact factor: 3.378

9.  Comparative pharmacokinetics of new quinolones.

Authors:  H Lode; G Höffken; C Prinzing; P Glatzel; R Wiley; P Olschewski; B Sievers; D Reimnitz; K Borner; P Koeppe
Journal:  Drugs       Date:  1987       Impact factor: 9.546

10.  Fungal transformations of antihistamines: metabolism of methapyrilene, thenyldiamine and tripelennamine to N-oxide and N-demethylated derivatives.

Authors:  C E Cerniglia; E B Hansen; K J Lambert; W A Korfmacher; D W Miller
Journal:  Xenobiotica       Date:  1988-03       Impact factor: 1.908
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  14 in total

1.  Identification of metabolites produced from N-phenylpiperazine by Mycobacterium spp.

Authors:  M D Adjei; J Deck; T M Heinze; J P Freeman; A J Williams; J B Sutherland
Journal:  J Ind Microbiol Biotechnol       Date:  2006-12-22       Impact factor: 3.346

2.  Modification of norfloxacin by a Microbacterium sp. strain isolated from a wastewater treatment plant.

Authors:  Dae-Wi Kim; Thomas M Heinze; Bong-Soo Kim; Laura K Schnackenberg; Kellie A Woodling; John B Sutherland
Journal:  Appl Environ Microbiol       Date:  2011-07-01       Impact factor: 4.792

3.  Biodegradation potential of ofloxacin and its resulting transformation products during photolytic and photocatalytic treatment.

Authors:  M I Vasquez; E Hapeshi; D Fatta-Kassinos; K Kümmerer
Journal:  Environ Sci Pollut Res Int       Date:  2012-08-02       Impact factor: 4.223

4.  Transformation of N-phenylpiperazine by mixed cultures from a municipal wastewater treatment plant.

Authors:  Carina M Jung; Thomas M Heinze; Joanna Deck; Ruth Strakosha; John B Sutherland
Journal:  Appl Environ Microbiol       Date:  2008-08-01       Impact factor: 4.792

5.  Microbial Metabolism of Atovaquone and Cytotoxicity of the Produced Phase I Metabolite.

Authors:  Eliane de Oliveira Silva; Natália Dos Santos Gonçalves; Raquel Alves Dos Santos; Niege Araçari Jacometti Cardoso Furtado
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2016-10       Impact factor: 2.441

Review 6.  Microbial transformations of antimicrobial quinolones and related drugs.

Authors:  Igor A Parshikov; John B Sutherland
Journal:  J Ind Microbiol Biotechnol       Date:  2012-09-25       Impact factor: 3.346

7.  Enrofloxacin degradation in broiler chicken manure under various laboratory conditions.

Authors:  Marko Slana; Marija Sollner-Dolenc
Journal:  Environ Sci Pollut Res Int       Date:  2015-10-27       Impact factor: 4.223

8.  Metabolite proving fungal cleavage of the aromatic core part of a fluoroquinolone antibiotic.

Authors:  Heinz-Georg Wetzstein; Josef Schneider; Wolfgang Karl
Journal:  AMB Express       Date:  2012-01-03       Impact factor: 3.298

9.  Hydroxylation of 1,8-cineole by Mucor ramannianus and Aspergillus niger.

Authors:  Aline de Souza Ramos; Joyce Benzaquem Ribeiro; Bruna Gomes Teixeira; José Luiz Pinto Ferreira; Jefferson Rocha de A Silva; Alexandre do Amaral Ferreira; Rodrigo Octavio Mendonça Alves de Souza; Ana Claudia F Amaral
Journal:  Braz J Microbiol       Date:  2015-03-01       Impact factor: 2.476

10.  Synthesis of ciprofloxacin-conjugated poly (L-lactic acid) polymer for nanofiber fabrication and antibacterial evaluation.

Authors:  Sharad P Parwe; Priti N Chaudhari; Kavita K Mohite; Balaji S Selukar; Smita S Nande; Baijayantimala Garnaik
Journal:  Int J Nanomedicine       Date:  2014-03-26
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