| Literature DB >> 10823757 |
K S MacDonald1, K R Fowke, J Kimani, V A Dunand, N J Nagelkerke, T B Ball, J Oyugi, E Njagi, L K Gaur, R C Brunham, J Wade, M A Luscher, P Krausa, S Rowland-Jones, E Ngugi, J J Bwayo, F A Plummer.
Abstract
Certain human leukocyte antigens, by presenting conserved immunogenic epitopes for T cell recognition, may, in part, account for the observed differences in human immunodeficiency virus type 1 (HIV-1) susceptibility. To determine whether HLA polymorphism influences HIV-1 susceptibility, a longitudinal cohort of highly HIV-1-exposed female sex workers based in Nairobi, Kenya, was prospectively analyzed. Decreased HIV-1 infection risk was strongly associated with possession of a cluster of closely related HLA alleles (A2/6802 supertype; incidence rate ratio [IRR], 0.45; 95% confidence interval [CI], 0.27-0.72; P=.0003). The alleles in this supertype are known in some cases to present the same peptide epitopes for T cell recognition. In addition, resistance to HIV-1 infection was independently associated with HLA DRB1*01 (IRR, 0.22; 95% CI, 0.06-0.60; P=.0003), which suggests that anti-HIV-1 class II restricted CD4 effector mechanisms may play an important role in protecting against viral challenge. These data provide further evidence that resistance to HIV-1 infection in this cohort of sex workers is immunologically mediated.Entities:
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Year: 2000 PMID： 10823757 DOI： 10.1086/315472
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226