| Literature DB >> 10817745 |
T Dey1, K Anam, F Afrin, N Ali.
Abstract
Here we report the activity of liposomes comprising egg phosphatidylcholine (PC) and stearylamine (SA) against Leishmania donovani parasites. Both promastigotes and intracellular amastigotes in vitro and in vivo were susceptible to SA-PC liposomes. A single dose of 55 mg of SA-PC liposomes/animal could significantly reduce the hepatic parasite burden by 85 and 68% against recent and established experimental visceral leishmaniasis, respectively, suggesting their strong therapeutic potential.Entities:
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Year: 2000 PMID: 10817745 PMCID: PMC89949 DOI: 10.1128/AAC.44.6.1739-1742.2000
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191